Results 111 to 120 of about 307,627 (269)

Higher-order group synchronization

Research in the Mathematical Sciences
Abstract Group synchronization is the problem of determining reliable global estimates from noisy local measurements on networks. The typical task for group synchronization is to assign elements of a group to the nodes of a graph in a way that respects group elements given on the edges which encode information ...
Adriana L. Duncan, Joe Kileel 0001
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Shift models for dose-finding in partially ordered groups. [PDF]

Clin Trials, 2019
Horton BJ, Wages NA, Conaway MR.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Atomic-precision π-driven peptide hydrogel nanofibers with ordered water channels

Nature Communications
Aromatic interactions organize molecules into ordered supramolecular architectures, while peptides form functional soft materials through hydrogen bonding and water-mediated assembly.
Ayaka Ueda, George Broutzakis, Alexander Neuhaus, David Ens, Dominik Mählmann, Lisa Schlichter, Hideya Kono, Akiko Yagi, Kazuma Amaike, Christos Gatsogiannis, Bart Jan Ravoo, Kenichiro Itami   +11 more
doaj   +1 more source

Moderating Effects of Visual Order in Graphical Symbol Complexity: The Practical Implications for Design

Applied Sciences
In the field of visual graphic design, complexity plays a crucial role in visual information processing, and it is assumed to be an absolute quantity based on the number of the presenting features and components.
Nuowen Zhang, Jing Zhang, Shangsong Jiang, Xingcheng Di, Weijun Li   +4 more
doaj   +1 more source

Rapid enrollment design for finding the optimal dose in immunotherapy trials with ordered groups. [PDF]

J Biopharm Stat, 2019
Xue X, Foster MC, Ivanova A.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Biological Surface Layer Formation on Bioceramic Particles for Protein Adsorption

Biomimetics
In the biomedical fields of bone regenerative therapy, the immobilization of proteins on the bioceramic particles to maintain their highly ordered structures is significantly important.
Reo Kimura, Daichi Noda, Zizhen Liu, Wanyu Shi, Ryota Akutsu, Motohiro Tagaya   +5 more
doaj   +1 more source