Results 81 to 90 of about 52,901 (306)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Perturbation of domain: ordinary differential equations [PDF]

Proceedings of the Royal Society of Edinburgh: Section A Mathematics, 2002
We study a boundary perturbation problem for a one-dimensional Schrödinger equation in which the potential has a regular singularity near the perturbed end point. We give the asymptotic behaviour of the eigenvalues under the perturbation. This problem arose out of the author's studies of singular elliptic operators in higher dimensions and we ...
openaire   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

On the derivation of the formula for the general solution of an ordinary linear differential equation with constant coefficients

Известия высших учебных заведений. Поволжский регион: Физико-математические науки
Background. Linear differential equations with constant coefficients are often used to solve a number of physical, engineering, chemical and biological problems.
Dostonjon N. Barotov, Ruziboy N. Barotov
doaj   +1 more source

On a list of ordinary differential equations problems [PDF]

São Paulo Journal of Mathematical Sciences, 2018
This evocative essay focuses on the mathematical activities witnessed by the author along 1962-64 at IMPA. The list of research problems proposed in September 1962 by Mauricio Peixoto at the Seminar on the Qualitative Theory of Differential Equations is pointed out as a landmark for the genesis of the research interest in the Qualitative Theory of ...
openaire   +3 more sources

On the differential invariants of a linear ordinary differential equation [PDF]

, 1981
SynopsisLet y(n) + a1y(n−1 +…+ an−1y(1) + an = 0 (*) be a linear ordinary differential equation of order n. A (relative) differential invariant of (*) is a differential polynomial function π(xi) defined on the solution space of (*) satisfying: there is ...
Gian-Carlo Rota, Joseph P. S. Kung
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Some problems in irregular ordinary differential equations [PDF]

We study the non-autonomous ordinary differential equation x = f (t, x) in the situation when the vector field f is of limited regularity, typically belonging to a space LP (O,T; Lq (JRn)).
Sharples, Nicholas
core  

On one class of solvable boundary value problems for ordinary differential equation of $n$-th order [PDF]

, 1994
summary:New sufficient conditions of the existence and uniqueness of the solution of a boundary problem for an ordinary differential equation of $n$-th order with certain functional boundary conditions are constructed by the method of a priori ...
Tuan, Nguyen Anh
core  

Almost sure exponential stability of numerical solutions for stochastic delay differential equations [PDF]

, 2010
Using techniques based on the continuous and discrete semimartingale convergence theorems, this paper investigates if numerical methods may reproduce the almost sure exponential stability of the exact solutions to stochastic delay differential equations (
Szpruch, Lukasz, Wu, Fuke, Mao, Xuerong
core   +1 more source