Results 101 to 110 of about 52,901 (306)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A Universal Ordinary Differential Equation [PDF]

, 2017
An astonishing fact was established by Lee A. Rubel (1981): there exists a fixed non-trivial fourth-order polynomial differential algebraic equation (DAE) such that for any positive continuous function phi on the reals, and for any positive continuous ...
Bournez, O., Pouly, A., Pouly, Amaury, Bournez, Olivier   +3 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Differential Transform Algorithm for Functional Differential Equations with Time-Dependent Delays

Complexity, 2020
An algorithm using the differential transformation which is convenient for finding numerical solutions to initial value problems for functional differential equations is proposed in this paper.
Josef Rebenda, Zuzana Pátíková
doaj   +1 more source

Differential/Algebraic Equations As Stiff Ordinary Differential Equations

SIAM Journal on Numerical Analysis, 1992
To a system of differential algebraic equations: \[ \text{(DAE)}\quad y'(t)=f(t,y(t),z(t),0),\quad g(t,y(t),z(t),0)=0, \] a system of singularly perturbed ordinary differential equations: \[ \text{(ODE)}\quad y_ \varepsilon'(t)=f(t,y_ \varepsilon(t),z_ \varepsilon(t),\varepsilon), \varepsilon z_ \varepsilon'(t)=g(t,y_ \varepsilon(t),z_ \varepsilon(t ...
openaire   +3 more sources

Statistical-grey consistent grey differential equation modelling [PDF]

, 2007
Includes abstract. Includes bibliographical references (p. 152-156)
Cui, Yan Hong
core  

On a Schwarzian PDE associated with the KdV hierarchy [PDF]

, 2000
We present a novel integrable non-autonomous partial differential equation of the Schwarzian type, i.e. invariant under M\"obius transformations, that is related to the Korteweg-de Vries hierarchy.
Hone, A. N. W., Nijhoff, F., Nijhoff, Frank W., Joshi, Nalini, Frank Nijhoff, Joshi, N., Andrew Hone, Nalini Joshi, Hone, Andrew N.W.   +8 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source