Results 51 to 60 of about 2,195,788 (280)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Bispectral commutative ordinary differential operators.

Journal für die reine und angewandte Mathematik (Crelles Journal), 1993
Let \(A\) be a commutative algebra of ordinary differential operators. We say \(A\) is bispectral if there is a family \(\psi(x,z)\) of joint eigenfunctions for the operators in \(A\) that also satisfies a differential equation of the form \(\Lambda\psi= \theta(x)\psi\), where \(\Lambda\) is some ordinary differential operator in the spectral parameter
openaire   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Functional Determinants for Radially Separable Partial Differential Operators

Acta Polytechnica, 2007
Functional determinants of differential operators play a prominent role in many fields of theoretical and mathematical physics, ranging from condensed matter physics, to atomic, molecular and particle physics.
G. V. Dunne
doaj  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Cyclic (noncyclic) phi-condensing operator and its application to a system of differential equations

Nonlinear Analysis, 2019
We establish a best proximity pair theorem for noncyclic φ-condensing operators in strictly convex Banach spaces by using a measure of noncompactness. We also obtain a counterpart result for cyclic φ-condensing operators in Banach spaces to guarantee the
Moosa Moosa Gabeleh, Philemon Moshokoa, Calogero Vetro   +2 more
doaj   +3 more sources

Solution of the inverse spectral problem for differential operators on a finite interval with complex weights [PDF]

Известия Саратовского университета. Новая серия: Математика. Механика. Информатика
Non-self-adjoint second-order ordinary differential operators on a finite interval with complex weights are studied. Properties of spectral characteristics are established, and the inverse problem of recovering operators from their spectral ...
Yurko, Vjacheslav Anatol'evich
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Characterization of domains of symmetric and self-adjoint ordinary differential operators

Electronic Journal of Differential Equations, 2018
We characterize the two point boundary conditions which determine symmetric ordinary differential operators of any order, even or odd, with complex coefficients and arbitrary deficiency index, in a Hilbert space.The self-adjoint characterizations ...
Aiping Wang, Anton Zettl
doaj