Results 61 to 70 of about 5,984 (300)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cyclic (noncyclic) phi-condensing operator and its application to a system of differential equations
Nonlinear Analysis, 2019 We establish a best proximity pair theorem for noncyclic φ-condensing operators in strictly convex Banach spaces by using a measure of noncompactness. We also obtain a counterpart result for cyclic φ-condensing operators in Banach spaces to guarantee the
Moosa Moosa Gabeleh +2 more
doaj +3 more sources
Solution of the inverse spectral problem for differential operators on a finite interval with complex weights [PDF]
Известия Саратовского университета. Новая серия: Математика. Механика. ИнформатикаNon-self-adjoint second-order ordinary differential operators on a finite interval with complex weights are studied. Properties of spectral characteristics are established, and the inverse problem of recovering operators from their spectral ...
Yurko, Vjacheslav Anatol'evich
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2013 Ordinary differential equations (ODEs) play an important role in mathematics. Although intrinsically, the setting for describing ODEs is the continuous framework, where differential operators are considered as maps from one function space to another ...
Birkisson, Asgeir
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Electronic Journal of Differential Equations, 2012 A Picone-type inequality for quasilinear elliptic operators with mixed nonlinearities and with p(x)-Laplacian is established, and Sturmian comparison theorems are derived on the basis of the Picone-type inequality.
Norio Yoshida
doaj
Spectral theory of singular ordinary differential operators
, 1989 SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische ...
Gesellschaft fuer Mathematische Forschung e.V., Oberwolfach (Germany). Mathematisches Forschungsinstitut
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 2008 We establish analogues of Hardy and Littlewood's integro-differential equation for Schrödinger-type operators on metric and discrete trees, based on a generalised strong limit-point property of the graph ...
Matthias Langer +7 more
core +1 more source