Results 61 to 70 of about 4,356 (261)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Fredholm linear operators associated with ordinary differential equations on noncompact intervals

Electronic Journal of Differential Equations, 1999
In the noncompact interval $J=[a,infty )$ we consider a linear problem of the form $Lx=y,; x in S$, where $L$ is a first order differential operator, $y$ a locally summable function in $J$, and $S$ a subspace of the Fr'{e}chet space of the locally ...
Mariella Cecchi, Massimo Furi, Mauro Marini, Maria Patrizia Pera   +3 more
doaj  

The nonlocal problem for the differential-operator equation of the even order with the involution

Karpatsʹkì Matematičnì Publìkacìï, 2018
In this paper, the problem with boundary nonself-adjoint conditions for a differential-operator equations of the order $2n$ with involution is studied. Spectral properties of operator of the problem is investigated.
Ya.O. Baranetskij, P.I. Kalenyuk, L.I. Kolyasa, M.I. Kopach   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Perturbation of ordinary differential operators

Journal of Mathematical Analysis and Applications, 1966
AbstractA perturbation theorem is proved which enables us to extend the results of J. Schwartz and others, to the effect that a wide class of boundary value problems for ordinary differential operators with operator valued coefficients generate unbounded spectral operators in the L2 space over a finite interval.
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Computation of Green's matrices for boundary value problems associated with a pair of mixed linear regular ordinary differential operators

International Journal of Mathematics and Mathematical Sciences, 1995
An algorithm for the computation of Green's matrices for boundary value problems associated with a pair of mixed linear regular ordinary differential operators is presented and two examples from the studies of acoustic waveguides in ocean and transverse ...
T. Gnana Bhaskar, M. Venkatesulu
doaj   +1 more source

On the approximation of isolated eigenvalues of ordinary differential operators [PDF]

Proceedings of the American Mathematical Society, 2008
We extend a result of Stolz and Weidmann on the approximation of isolated eigenvalues of singular Sturm-Liouville and Dirac operators by the eigenvalues of regular operators.
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source