Results 71 to 80 of about 2,195,788 (280)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Fredholm linear operators associated with ordinary differential equations on noncompact intervals

Electronic Journal of Differential Equations, 1999
In the noncompact interval $J=[a,infty )$ we consider a linear problem of the form $Lx=y,; x in S$, where $L$ is a first order differential operator, $y$ a locally summable function in $J$, and $S$ a subspace of the Fr'{e}chet space of the locally ...
Mariella Cecchi, Massimo Furi, Mauro Marini, Maria Patrizia Pera   +3 more
doaj  

The nonlocal problem for the differential-operator equation of the even order with the involution

Karpatsʹkì Matematičnì Publìkacìï, 2018
In this paper, the problem with boundary nonself-adjoint conditions for a differential-operator equations of the order $2n$ with involution is studied. Spectral properties of operator of the problem is investigated.
Ya.O. Baranetskij, P.I. Kalenyuk, L.I. Kolyasa, M.I. Kopach   +3 more
doaj   +1 more source

Perturbation of ordinary differential operators

Journal of Mathematical Analysis and Applications, 1966
AbstractA perturbation theorem is proved which enables us to extend the results of J. Schwartz and others, to the effect that a wide class of boundary value problems for ordinary differential operators with operator valued coefficients generate unbounded spectral operators in the L2 space over a finite interval.
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Computation of Green's matrices for boundary value problems associated with a pair of mixed linear regular ordinary differential operators

International Journal of Mathematics and Mathematical Sciences, 1995
An algorithm for the computation of Green's matrices for boundary value problems associated with a pair of mixed linear regular ordinary differential operators is presented and two examples from the studies of acoustic waveguides in ocean and transverse ...
T. Gnana Bhaskar, M. Venkatesulu
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

INTEGRAL METHOD OF SOLVING HEAT-CONDUCTION PROBLEMS WITH THE SECOND-KIND BOUNDARY CONDITION. 1. BASIC STATEMENTS

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2018
On the basis of systems of identical equalities and integral boundary characteristics, a new algorithm of solving a boundary-value problem on the nonstationary heat conduction in a canonical body with boundary condition of the second kind has been ...
V. A. Kot
doaj   +1 more source