Results 81 to 90 of about 2,195,788 (280)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Analytical method for solving linear abstract differential equations of order n

open access: yesPartial Differential Equations in Applied Mathematics
In this paper, the concept of point-wise independent set of closed operators is introduced. The new concept together with the use of Hahn–Banach Theorem enable us to reduce an inhomogeneous linear abstract differential equation of order n namely, Anu(n ...
Waseem Ghazi Alshanti   +3 more
doaj   +1 more source

Monotone increasing multi-valued condensing random operators and random differential inclusions

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2006
In this paper, some random fixed point theorems for monotone increasing, condensing and closed multi-valued random operators are proved. They are then applied to first order ordinary nonconvex random differential inclusions for proving the existence of ...
Bapurao Dhage   +2 more
doaj   +1 more source

On the approximation of isolated eigenvalues of ordinary differential operators [PDF]

open access: yesProceedings of the American Mathematical Society, 2008
We extend a result of Stolz and Weidmann on the approximation of isolated eigenvalues of singular Sturm-Liouville and Dirac operators by the eigenvalues of regular operators.
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Andrzej Lasota's selected results [PDF]

open access: yesOpuscula Mathematica, 2008
In this article we recall Andrzej Lasota's selected results which either indicated new directions of research, or layed the foundations for new approaches, or solved interesting problems. The area of mathematical interests of Professor Andrzej Lasota was
Józef Myjak
doaj  

A remark on rational Cherednik algebras and differential operators on the cyclic quiver [PDF]

open access: yes, 2006
We show that the spherical subalgebra Uk,c of the rational Cherednik algebra associated to Sn 2 Cl, the wreath product of the symmetric group and the cyclic group of order l, is isomorphic to a quotient of the ring of invariant differential operators on ...
Gordon, I.
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Peano Theorems for Pedjeu–Ladde-Type Multi-Time Scale Stochastic Differential Equations Driven by Fractional Noises

open access: yesMathematics
This paper examines fractional multi-time scale stochastic functional differential equations that, in addition, are driven by fractional noises. Based on a specially crafted fixed-point principle for the so-called “local operators”, we prove a Peano-type
Arcady Ponosov, Lev Idels
doaj   +1 more source

Home - About - Disclaimer - Privacy