Results 81 to 90 of about 138,809 (284)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The nonlocal problem for the differential-operator equation of the even order with the involution

Karpatsʹkì Matematičnì Publìkacìï, 2018
In this paper, the problem with boundary nonself-adjoint conditions for a differential-operator equations of the order $2n$ with involution is studied. Spectral properties of operator of the problem is investigated.
Ya.O. Baranetskij, P.I. Kalenyuk, L.I. Kolyasa, M.I. Kopach   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Invertible linear ordinary differential operators

Journal of Geometry and Physics, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Relative boundedness and compactness theory for second-order differential operators

Journal of Inequalities and Applications, 1997
The problem considered is to give necessary and sufficient conditions for perturbations of a second-order ordinary differential operator to be either relatively bounded or relatively compact. Such conditions are found for three classes of operators. The
Don B. Hinton, Terry G. Anderson
doaj   +2 more sources

Computation of Green's matrices for boundary value problems associated with a pair of mixed linear regular ordinary differential operators

International Journal of Mathematics and Mathematical Sciences, 1995
An algorithm for the computation of Green's matrices for boundary value problems associated with a pair of mixed linear regular ordinary differential operators is presented and two examples from the studies of acoustic waveguides in ocean and transverse ...
T. Gnana Bhaskar, M. Venkatesulu
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

INTEGRAL METHOD OF SOLVING HEAT-CONDUCTION PROBLEMS WITH THE SECOND-KIND BOUNDARY CONDITION. 1. BASIC STATEMENTS

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2018
On the basis of systems of identical equalities and integral boundary characteristics, a new algorithm of solving a boundary-value problem on the nonstationary heat conduction in a canonical body with boundary condition of the second kind has been ...
V. A. Kot
doaj   +1 more source