Results 121 to 130 of about 362,976 (244)

The role of the gut microbiome in the regulation of high‐altitude adaptation

iMeta, EarlyView.
This study is the first to elucidate mechanisms of high‐altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude since birth as comparative models. Through a systematic comparison of their rumen ecology using multi‐omics approaches—including rumen metagenomics ...
Xinyu Zhang, Senlin Zhu, Michael Kreuzer, Shoukun Ji, Wei Wang, Yanliang Bi, Shengli Li   +6 more
wiley   +1 more source

Escaping Constraints to Innovate: Maternal Neofunctionalization in a HoxB4 Duplicate

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Whole‐genome duplication in Xenopus laevis generated duplicated Hox genes that are largely constrained in sequence and developmental expression. However, HoxB4L uniquely acquired maternal expression through cis‐regulatory and protein structural divergence, illustrating how gene duplication enables transcription factors to escape pleiotropic constraints
Júlia de Lima Carvalho, José Caetano Silva‐Filho, Janaina Lima de Oliveira   +2 more
wiley   +1 more source

Eczema Monkeypoxicum Following Sexual Transmission Treated With Tecovirimat

JEADV Clinical Practice, EarlyView.
ABSTRACT Mpox is a zoonotic viral infection caused by monkeypox virus (MPXV) and risk factors for its dissemination include previous dermatoses such as atopic dermatitis [1]. We present the case of a 30‐year‐old male with an unusual and extensive presentation of mpox following unprotected sexual intercourse, with an excellent response to tecovirimat ...
Andrés Vidal González, Sergio López Alcázar, José Ángel Amat Sánchez, Francisco Vergara Barria, Rosa Feltes Ochoa, Elena Sendagorta Cudos, Pedro Herranz Pinto   +6 more
wiley   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

A rare case of human infection with Orf virus in China, 2024. [PDF]

Front Cell Infect Microbiol
Lu M, Liang Y, Zhou H, Jiang H, Wang X, Jiang W, Sun X, Zhong S, Li K.   +8 more
europepmc   +1 more source

Green Synthesis of ZnO Nanoparticles From Spirulina platensis: Antimicrobial and Cytotoxic Evaluation With Molecular Docking Studies

ChemistryOpen, EarlyView.
Algal‐extract‐derived ZnO nanoparticles show shape anisotropy and are bio capped by phytochemicals. These green‐synthesized NPs strongly inhibit S. aureus and K. pneumoniae biofilms. Molecular docking suggests stable binding of surface biomolecules to microbial targets, highlighting synergistic antibacterial mechanisms.
Muhammad Rizwan, Izaz Khan, Syed Sikandar Shah, Amir hamza khan, Abdurahman Hajinur Hirad, Saira Naz, Arshad Farid, Taimoor Khan, Said Hassan   +8 more
wiley   +1 more source

A prediction method for older adult care service demand combining improved RF algorithm and logistic regression. [PDF]

Front Public Health
Wang Y, Liu N.
europepmc   +1 more source

Impact of Organic and Inorganic Fillers on the Performance of Ternary Biodegradable Poly(Butylene Succinate‐Co‐Butylene Adipate), Poly(Butylene Adipate‐Co‐Terephthalate), and Poly(3‐Hydroxybutyrate‐Co‐3‐Hydroxyvalerate) Blends

Polymer Composites, EarlyView.
Development of a ternary blend composite based on PBAT/PBSA/PHVB with improved mechanical properties. ABSTRACT This study explores a ternary biodegradable blend of bio‐based poly(butylene succinate‐co‐adipate) (bio‐PBSA), poly(butylene adipate terephthalate) (PBAT), and poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV).
Sasha Paquette, Matias Menossi, Ehsan Pesaranhajiabbas, Hamdy Khalil, Manjusri Misra, Amar Kumar Mohanty   +5 more
wiley   +1 more source

Lethal effect of heterologous Haemonchus contortus α- and β-tubulin expression in Leishmania tarentolae. [PDF]

PLoS One
Borchert M, Krücken J, Müller M, von Samson-Himmelstjerna G.   +3 more
europepmc   +1 more source