Results 161 to 170 of about 465,444 (266)

Inhibition of PHF1 promotes ferroptosis via IRES‐dependent Snail translation regulation in pancreatic ductal adenocarcinoma

VIEW, EarlyView.
PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie, Shan Jin, Yao Zhan, Tiantian Du, Yaqi Dong, Peilong Li, Xiaoshi Zhang, Qiuchen Qi, Jie Gao, Chuanxin Wang   +9 more
wiley   +1 more source

Etymologia: Orf

Emerging Infectious Diseases, 2013
doaj   +1 more source

Lethal effect of heterologous Haemonchus contortus α- and β-tubulin expression in Leishmania tarentolae. [PDF]

PLoS One
Borchert M, Krücken J, Müller M, von Samson-Himmelstjerna G.   +3 more
europepmc   +1 more source

Optimized bacterial expression of a synthetic BRIL antibody

Acta Crystallographica Section F, EarlyView.
Here, we document the generation of a T7 Express ΔcybC strain allowing contaminant‐free expression of the anti‐BRIL Fab BAG2. We also report the crystal structure of BAG2 in complex with native cytochrome b562, a complex arising from expression in canonical Escherichia coli strains.The use of monoclonal fragments antigen binding (Fabs) is a prevalent ...
Benjamin F. Cooper, Georgia L. Isom
wiley   +1 more source

TRANSAID: a hybrid deep learning framework for translation site prediction with integrated biological feature scoring. [PDF]

Front Bioinform
Li Y, Wang B, Liu Z, Wei W, Fei C, Xu S, Han T, Geng W, Wu Z.   +8 more
europepmc   +1 more source

Inhibition of Targeted Bacterial Growth Using MazF‐Expressing Phagemids: A Novel Therapeutic Approach Based on Endoribonuclease Toxin Molecules

Microbiology and Immunology, EarlyView.
ABSTRACT The extensive and indiscriminate use of antibiotics, which are intended to halt bacterial growth or eliminate them, has unintentionally given rise to antimicrobial resistance (AMR), which is a critical threat to global health. In the pursuit of alternative solutions, researchers have focused on type II toxin–antitoxin systems prevalent within ...
Hana Hasegawa, Tatsuki Miyamoto, Rino Isshiki, Tomoyoshi Kaneko, Kenichi Takasugi, Naohiro Noda, Satoshi Tsuneda   +6 more
wiley   +1 more source

A new Epseptimavirus bacteriophage vB_SalS-SIY1lw as a potential antimicrobial alternative to multidrug-resistant Salmonella Infantis. [PDF]

Sci Rep
Liao YT, Voelker A, Arellano AR, Zhang Y, Harden LA, Salvador A, Wu VCH.   +6 more
europepmc   +1 more source

Molecular characterization of transformer, transformer‐2, and doublesex genes in the carambola fruit fly, Bactrocera carambolae, revealing potential for genetic pest management

Insect Science, EarlyView.
Abstract Globalization and climate change may be driving the spread of the quarantine fruit fly, Bactrocera carambolae, highlighting the need for ecofriendly control methods like the Sterile Insect Technique (SIT), which relies on releasing sterile males to reduce wild populations.
Kamoltip Laohakieat, Thanalai Poonsiri, Nidchaya Aketarawong   +2 more
wiley   +1 more source

Molecular mechanisms of sex determination in Lepidoptera: current status and perspectives

Insect Science, EarlyView.
The genetic basis of sex determination in Lepidoptera was discovered in 2014 in the silkworm Bombyx mori. In this model species, the W chromosome‐derived small piRNA called Fem piRNA downregulates the expression of a Z‐linked gene, Masculinizer (Masc), which leads to the default female‐specific splicing of the doublesex gene (dsxF) and thus to female ...
František Marec, Atsuo Yoshido, Arjen E. van′t Hof   +2 more
wiley   +1 more source

A novel ORF127/ORF130 gene deletion Orf virus vaccine candidate: construction and evaluation. [PDF]

Virol J
Wang G, Zhang J, Tian Q, Hu J, Wang Z, Wang Q.   +5 more
europepmc   +1 more source