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Tissue culture‐propagated orf virus vaccine protects lambs from orf virus challenge
Veterinary Record, 1996Twenty, eight‐day‐old specific pathogen‐free (SPF) lambs were vaccinated by a single scarification approximately 4 cm in length on the inner right thigh with a double‐pronged applicator. The titre of live virus in the vaccine was 10 7.2 TCID 50 /ml and ...
P F, Nettleton +5 more
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Recent advances in diagnostic approaches for orf virus
Applied Microbiology and Biotechnology, 2023Orf virus (ORFV), the prototype species of the Parapoxvirus genus, is an important zoonotic virus, causing great economic losses in livestock production. At present, there are no effective drugs for orf treatment. Therefore, it is crucial to develop accurate and rapid diagnostic approaches for ORFV.
Feng Pang, Qinqin Long
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Orf virus and vaccinia virus do not cross-protect sheep
Archives of Virology, 1988Inoculation of lambs with a New Zealand strain of orf virus (NZ 2) failed to protect them against subsequent infection with the Lister strain of vaccinia virus. Similarly, in the reciprocal test, vaccinia virus failed to protect against subsequent orf virus infection. Inoculation with either orf virus or vaccinia virus alone afforded protection against
A J, Robinson, A A, Mercer
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Therapeutic immunomodulation using a virus—the potential of inactivated orf virus
European Journal of Clinical Microbiology & Infectious Diseases, 2012Viruses can manipulate the immune response against them by various strategies to influence immune cells, i.e. by over-activation leading to functional inactivation, bypassing antigen presentation or even suppression of effector functions. Little is known, however, about how these features of immune regulation and modulation could be used for ...
O, Weber +4 more
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Orf virus infection and host immunity
Current Opinion in Infectious Diseases, 2006A summary of recent advances in our knowledge of the biology of orf virus is presented to illustrate the interaction of a zoonotic pathogen with host skin. This is providing novel and interesting data on the viral mechanism of skin infection and the host response.The full genome sequences of two parapoxviruses (orf virus and bovine papular stomatitis ...
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Studies of the pathogenesis of orf virus infection in sheep
Journal of Comparative Pathology, 1988Damage to the skin is essential for the establishment of orf virus infection and the development of typical lesions. However, analysis of the pathogenesis of experimental lesions induced by viral challenge of mildly abraded skin, indicated that the virus does not establish in the damaged epidermis, but replicates in the cells of an underlying ...
D J, McKeever +3 more
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Functional expression of the recombinant ATPase of orf virus
Archives of Virology, 2010Nucleotide sequence analysis has indicated that the A32L gene of orf virus can encode an ATPase (Chan et al. in Gene 432:44-53, 2009). In this work, we cloned the A32L gene into a prokaryotic expression vector, and the recombinant protein was expressed and purified. The antigenicity of recombinant ATPase was examined by immunoblotting, and its identity
Fong-Yuan, Lin +4 more
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Virus particles and antigens in experimental Orf scabs
Archiv f�r die gesamte Virusforschung, 1973Sequential observations of experimentally induced orf scabs on lambs revealed that complement-fixing antigens, precipitating antigens and virus particles all reached peak levels within one to two weeks. The most sensitive diagnostic technique was the detection of complement-fixing antigen.
C H, Romero-Mercado +4 more
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Gene homology between orf virus and smallpox variola virus
Virus Genes, 1996About 47% identity was observed between the deduced amino acid sequences of a protein encoded by a gene of the parapoxvirus orf virus (OV) strain NZ2 and a 6 kDa protein of unknown function reported to be produced by an open reading frame expressed early after infection by the orthopoxvirus Western Reserve vaccinia virus (VAC); the open reading frame ...
A A, Mercer, K M, Fraser, J J, Esposito
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A homologue of retroviral pseudoproteases in the parapoxvirus, orf virus
Virology, 1989The nucleotide sequence of a near-terminal region of orf virus DNA was determined. Examination of the sequence revealed an open reading frame encoding a peptide with significant amino acid homology to the pseudoprotease domains recently identified in a number of retroviruses including mouse mammary tumor virus, simian Mason-Pfizer virus, maedi-visna ...
A A, Mercer +3 more
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