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Immunomodulatory Strategies for Parapoxvirus: Current Status and Future Approaches for the Development of Vaccines Against Orf Virus Infection

Vaccines, 2021
Orf virus (ORFV), the prototype species of the parapoxvirus genus, is the causative agent of contagious ecthyma, an extremely devastating skin disease of sheep, goats, and humans that causes enormous economic losses in livestock production. ORFV is known
Krishnan Nair Balakrishnan, Faez Firdaus Abdullah Jesse, Che Azurahanim Che Abdullah   +2 more
exaly   +3 more sources

First identification of orf virus from an outbreak of contagious ecthyma in Polish sheep [PDF]

Journal of Veterinary Research
Contagious ecthyma (CE) is a skin disease of goats, sheep and some other domesticated and wild ruminants worldwide, including Poland. The infection is caused by the orf virus (ORFV) of the Parapoxvirus genus. It is characterised by the appearance of skin
Larska Magdalena, Nowakowska Agnieszka, Pękala-Duda Urszula   +2 more
doaj   +2 more sources

An Investigation of a Cluster of Parapoxvirus Cases in Missouri, Feb–May 2006: Epidemiologic, Clinical and Molecular Aspects

Animals, 2013
In the spring of 2006, four human cases of parapoxvirus infections in Missouri residents were reported to the Centers for Disease Control and Prevention (CDC), two of which were initially diagnosed as cutaneous anthrax.
Mary G. Reynolds, Christina L Hutson, Dana L Haberling   +2 more
exaly   +3 more sources

Equine Ulcerative Genital Lesions Associated with Parapoxvirus [PDF]

Viruses
In 2026, a widespread outbreak of ulcerative dermatitis of unknown aetiology occurred in breeding horses in Ireland. The lesions resembled those associated with equine herpesvirus 3 (EHV3) infection, i.e., papules, vesicles, and ulcers on the penis of ...
Ann Cullinane, Marie Garvey, Donald Collins, Rachel Lyons, Maura Nelly, Adam Grimes   +5 more
doaj   +2 more sources

Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity

Frontiers in Microbiology, 2019
Parapoxvirus of red deer in New Zealand (PVNZ) is a species of the Parapoxvirus genus that causes pustular dermatitis. We identified a cluster of genes in PVNZ that encode three unique chemokine-binding proteins (CBPs) namely ORF112.0, ORF112.3 and ...
Zabeen Lateef, Yoshio Nakatani, Lyn M Wise   +2 more
exaly   +3 more sources

Innate Immune Sensing of Parapoxvirus Orf Virus and Viral Immune Evasion [PDF]

Viruses
Orf virus (ORFV) is the type species of Parapoxvirus of the Poxviridae family that induces cutaneous pustular skin lesions in sheep and goats, and causes zoonotic infections in humans.
Basheer A. AlDaif, Stephen B. Fleming
doaj   +2 more sources

A Comparison of Parapoxviruses in North American Pinnipeds

Frontiers in Veterinary Science, 2021
Parapoxviruses cause nodular lesions on the skin and mucosal membranes of pinnipeds and infections by these viruses have been documented worldwide. Seal parapoxvirus is currently classified as a tentative species of the Parapoxvirus genus. Tissue or swab
Helena Costa, Helena Costa, Jörn Klein, Eva M. Breines, Hendrik H. Nollens, Keith Matassa, Mendy Garron, Padraig J. Duignan, Todd Schmitt, Tracey Goldstein, Morten Tryland   +10 more
doaj   +1 more source

Parapoxvirus Interleukin-10 Homologues Vary in Their Receptor Binding, Anti-Inflammatory, and Stimulatory Activities

Pathogens, 2022
Homologues of interleukin (IL)-10, a pleiotropic immunomodulatory cytokine, have been identified in the Parapoxvirus genus. The first identified, Orf virus (ORFV) IL-10, greatly enhanced infection of its host, exhibiting immune modulatory effects ...
Amreen Naqash, Gabriella Stuart, Roslyn Kemp, Lyn Wise   +3 more
doaj   +1 more source

Orf Nodule with Erythema Multiforme during a Monkeypox Outbreak, France, 2022

Emerging Infectious Diseases, 2023
A 26-year-old patient in France who worked as a butcher sought care initially for erythema multiforme. Clinical examination revealed a nodule with a crusty center, which upon investigation appeared to be an orf nodule.
Charlotte Cavalieri, Anne-Sophie Dupond, Audrey Ferrier-Rembert, Olivier Ferraris, Timothée Klopfenstein, Souheil Zayet   +5 more
doaj   +1 more source

Orf Virus-Based Vectors Preferentially Target Professional Antigen-Presenting Cells, Activate the STING Pathway and Induce Strong Antigen-Specific T Cell Responses

Frontiers in Immunology, 2022
BackgroundOrf virus (ORFV)-based vectors are attractive for vaccine development as they enable the induction of potent immune responses against specific transgenes. Nevertheless, the precise mechanisms of immune activation remain unknown.
Melanie Müller, Alena Reguzova, Markus W. Löffler, Markus W. Löffler, Markus W. Löffler, Markus W. Löffler, Ralf Amann   +6 more
doaj   +1 more source