Results 61 to 70 of about 104,420 (304)

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants

Clinical and Translational Science, 2020
Single nucleotide variants in the open reading frames (ORFs) of pharmacogenes are important causes of interindividual variability in drug response. The functional characterization of variants of unknown significance within ORFs remains a major challenge ...
Lingxin Zhang, Vivekananda Sarangi, Irene Moon, Jia Yu, Duan Liu, Sandhya Devarajan, Joel M. Reid, Krishna R. Kalari, Liewei Wang, Richard Weinshilboum   +9 more
doaj   +1 more source

Step-wise clustering of GOS ORFs.

, 2013
Step-wise clustering of GOS ORFs.
Weizhong Li (10010), Adam Godzik (4285), John C. Wooley (247811)   +2 more
core   +1 more source

Differentially-expressed ORFs upon perRB inactivation.

, 2021
Differentially-expressed ORFs upon perRB inactivation.
Samuel G. Huete (9465431), Giovanni Bussotti (45579), Jean-Yves Coppée (841975), Antony T. Vincent (3251520), Rachel Legendre (4596208), Mathieu Picardeau (32310), Crispin Zavala-Alvarado (9465428), Hugo Varet (816197), Pierre Lechat (4667086), Nadia Benaroudj (2590069), Frédéric J. Veyrier (8180946), Odile Sismeiro (12747), Céline Lorioux (11784692)   +12 more
core   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Genomic comparison of invasive and rare non-invasive strains reveals Porphyromonas gingivalis genetic polymorphisms

Journal of Oral Microbiology, 2011
Porphyromonas gingivalis strains are shown to invade human cells in vitro with different invasion efficiencies, varying by up to three orders of magnitude.We tested the hypothesis that invasion-associated interstrain genomic polymorphisms are present in ...
Svetlana Dolgilevich, Brian Rafferty, Darya Luchinskaya, Emil Kozarov   +3 more
doaj   +1 more source

Detection of conjugation related type four secretion machinery in Aeromonas culicicola. [PDF]

PLoS ONE, 2006
BACKGROUND: Aeromonas sp. can now be considered relatively common enteropathogens due to the increase of diseases in humans. Aeromonas culicicola is a gram negative rod-shaped bacterium isolated for the first time from the mosquito mid-gut, but ...
Ashraf Yusuf Rangrez, Kannayakanahalli Maheshwarappa Dayananda, Santosh Atanur, Rajendra Joshi, Milind S Patole, Yogesh S Shouche   +5 more
doaj   +1 more source

All predicted Prochlorococcus ORFs, nucleotide sequence

, 2014
Set of nucleotide FASTA files containing the predicted nucleotide sequence for all open reading frames (ORFs) in each genome. This file includes ORFs from both the new genomes presented here as well as the re-annotation of previously released ...
Steven J. Biller (3261984), Libusha Kelly (61267), Kathryn H. Roache-Johnson (3313827), Roache-Johnson, Kathryn H., Sara E. Roggensack (789029), Jessie W. Berta-Thompson (3313824), Chisholm, Sallie W., Lana Awad (3313830), Awad, Lana, Giovannoni, Stephen J., Sallie W. Chisholm (53467), Paul M. Berube (3313821), Roggensack, Sara E., Moore, Lisa R., Berta-Thompson, Jessie W., Kelly, Libusha, Stephen J. Giovannoni (208499), Biller, Steven J., Ding, Huiming, Huiming Ding (196523), Berube, Paul M., Lisa R. Moore (3313833)   +21 more
core   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

UPF1 regulates mRNA stability by sensing poorly translated coding sequences

Cell Reports
Summary: Post-transcriptional mRNA regulation shapes gene expression, yet how cis-elements and mRNA translation interface to regulate mRNA stability is poorly understood.
Damir Musaev, Mario Abdelmessih, Charles E. Vejnar, Valeria Yartseva, Linnea A. Weiss, Ethan C. Strayer, Carter M. Takacs, Antonio J. Giraldez   +7 more
doaj   +1 more source