Results 91 to 100 of about 790,004 (346)
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
APL Bioengineering, 2020 Organ-on-a-chip (OoC) systems have evolved to a promising alternative to animal testing and traditional cell assays in drug development and enable personalization for precision medicine.
Stefan Schneider +4 more
doaj +1 more source
Human-Derived Organ-on-a-Chip for Personalized Drug Development.
Current pharmaceutical design, 2019 To reduce the required capital and time investment in the development of new pharmaceutical agents, there is an urgent need for preclinical drug testing models that are predictive of drug response in human tissues or organs.
Yasamin A. Jodat +7 more
semanticscholar +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Polymerase Chain Reaction and blood culture for diagnosis of canine sepsis
Ciência Rural, 2018 : Sepsis is characterized by the presence of organ dysfunction secondary to the dysregulated systemic inflammatory response associated with an infection, and has high mortality rates.
Marcelo Marques da Silveira +8 more
doaj +1 more source
Length-weight relationship and organ indices of pond raised and wild population of C. gariepinus (Burchell 1822) pisces-Claridae [PDF]
, 1999 Samples of C. gariepinus collected from the wild and cultured populations in Plateau and Niger States of Nigeria were analyzed for length-weight relationship and organ indices (Gonadosomatic index (GSI), hepatosomatic index (HSI), renalsomatic index (RSI)
Tsadu, S.M.
core
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
A Brief History of Cell Culture: From Harrison to Organs-on-a-Chip
CellsThis comprehensive overview of the historical milestones in cell culture underscores key breakthroughs that have shaped the field over time. It begins with Wilhelm Roux’s seminal experiments in the 1880s, followed by the pioneering efforts of Ross ...
Lincoln Gozzi Moro +8 more
doaj +1 more source
Angiogenesis in tissue engineering : Breathing life into constructed tissue substitutes [PDF]
, 2006 Long-term function of three-dimensional (3D) tissue constructs depends on adequate vascularization after implantation. Accordingly, research in tissue engineering has focused on the analysis of angiogenesis.
Amon, Michaela +15 more
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source