Results 91 to 100 of about 801,709 (375)
The Surgical Infection Society revised guidelines on the management of intra-abdominal infection [PDF]
, 2017 Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update
Chang, Phillip K +11 more
core +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Microphysiological systems in absorption, distribution, metabolism, and elimination sciences
Clinical and Translational Science, 2022 The use of microphysiological systems (MPS) to support absorption, distribution, metabolism, and elimination (ADME) sciences has grown substantially in the last decade, in part driven by regulatory demands to move away from traditional animal‐based ...
Kirk P. Van Ness +4 more
doaj +1 more source
The Value of the Dead: The Commodification of Corpses in Western Culture [PDF]
, 2018 Since the 19th century, the deceased human body and its parts have been increasingly dehumanized, objectified, and commodified in Western culture. Thus, in a relatively short period of time, the corpse became, and continues to be, a highly valuable ...
Wallace, Charles Z.
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plant Secondary metabolites production by in vitro culture
Biotecnología Vegetal, 2011 Plant cell and tissue cultures are considered as an alternative source to the whole plant for the production of valuable compounds. Undifferentiated cell cultures have been extensively studied, but a large interest has also been shown in hairy roots and ...
Naivy Pérez-Alonso, Elio Jiménez
doaj
Evaluation of Somatic Embryogenesis Ability in Robusta Coffee (Coffea Canephora Pierre) [PDF]
, 2010 Embriogenesis somatik diharapkan sebagai metode perbanyakan tanaman yang sangat efektif pada kopi. Evaluasi dua jenis proses embriogenesis somatik, yaitu proses langsung dan tidak langsung akan bermanfaat untuk menggambarkan kemampuan proliferasi sel ...
Priyono, P. (Priyono)
core +3 more sources
Revolutionizing immune research with organoid-based co-culture and chip systems
Clinical and Experimental ImmunologySummary The intertwined interactions various immune cells have with epithelial cells in our body require sophisticated experimental approaches to be studied.
Diana Papp +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Human-Derived Organ-on-a-Chip for Personalized Drug Development.
Current pharmaceutical design, 2019 To reduce the required capital and time investment in the development of new pharmaceutical agents, there is an urgent need for preclinical drug testing models that are predictive of drug response in human tissues or organs.
Yasamin A. Jodat +7 more
semanticscholar +1 more source