Results 81 to 90 of about 790,004 (346)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Integrative biological simulation praxis: Considerations from physics, philosophy, and data/model curation practices [PDF]
, 2017 Integrative biological simulations have a varied and controversial history in the biological sciences. From computational models of organelles, cells, and simple organisms, to physiological models of tissues, organ systems, and ecosystems, a diverse ...
Faundez, Victor, Sarma, Gopal P.
core +2 more sources
Key role for inhibins in effective T cell activation, migration and Th17 differentiation
FEBS Open Bio, EarlyView.Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco +5 more
wiley +1 more source
Microphysiological systems in absorption, distribution, metabolism, and elimination sciences
Clinical and Translational Science, 2022 The use of microphysiological systems (MPS) to support absorption, distribution, metabolism, and elimination (ADME) sciences has grown substantially in the last decade, in part driven by regulatory demands to move away from traditional animal‐based ...
Kirk P. Van Ness +4 more
doaj +1 more source
Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia [PDF]
, 1976 In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there
Hansbrough, JF +5 more
core +1 more source
FEBS Open Bio, EarlyView.Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová +11 more
wiley +1 more source
A Technique to Establish a Bacterial Infection Model in an Ex Vivo Organ Culture [PDF]
, 2023 openalex +1 more source
Revolutionizing immune research with organoid-based co-culture and chip systems
Clinical and Experimental ImmunologySummary The intertwined interactions various immune cells have with epithelial cells in our body require sophisticated experimental approaches to be studied.
Diana Papp +2 more
semanticscholar +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
Plant Secondary metabolites production by in vitro culture
Biotecnología Vegetal, 2011 Plant cell and tissue cultures are considered as an alternative source to the whole plant for the production of valuable compounds. Undifferentiated cell cultures have been extensively studied, but a large interest has also been shown in hairy roots and ...
Naivy Pérez-Alonso, Elio Jiménez
doaj