Results 61 to 70 of about 9,960,236 (306)

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Plant organ cultures as masked mycotoxin biofactories: Deciphering the fate of zearalenone in micropropagated durum wheat roots and leaves. [PDF]

PLoS ONE, 2017
"Masked mycotoxins" senso strictu are conjugates of mycotoxins resulting from metabolic pathways activated by the interplay between pathogenic fungi and infected plants.
Laura Righetti, Enrico Rolli, Gianni Galaverna, Michele Suman, Renato Bruni, Chiara Dall'Asta   +5 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Comparative Assessment of the Cytotoxicity of Various Substrates in Organ Culture and Cell Culture: A Scanning Electron Microscopy Study [PDF]

, 1992
A comparative study of the behavior of chick embryo endothelial cells grown on various substrates was performed in order to establish the reliability and the limitation of both cell and organ culture methods. Following substrates were analyzed to compare
Sigot-Luizard, M. F., Duval, J. L., Warocquier-Clerout, R.   +2 more
core   +1 more source

Supplementary material. Autologous iPSC-derived four-organ-chip

, 2019
Supplementary material. Autologous iPSC-derived four-organ-chipMicrophysiological systems play a pivotal role in progressing towards a global paradigm shift in drug development.
Lin, Grace (7363457), Grabovica, Alexandra (7363454), Hasenberg, Tobias (7363430), Pabinger, Stephan (7363460), Lauster, Roland (7363466), Drewell, Christopher (7363448), Lorenz, Alexandra (7363442), Schwenk, Christine (7363433), Magauer, Corinna (7363436), Neuhaus, Winfried (7363463), Bois, Frederic (5776781), Schirrmann, Kerstin (7363451), Ramme, Anja (7363424), Faust, Daniel (7363439), Marx, Uwe (7363469), Dehne, Eva-Maria (7363472), Koenig, Leopold (7363427), Krebs, Anna (7363445)   +17 more
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Influence of Organ Culture on the Characteristics of the Human Limbal Stem Cell Niche

, 2023
Organ culture storage techniques for corneoscleral limbal (CSL) tissue have improved the quality of corneas for transplantation and allow for longer storage times.
Eva Ulrich, Polisetti, Naresh, Gottfried Martin, Schlunck, Günther, Reinhard, Thomas, Ursula Schlötzer-Schrehardt, Glegola, Mateusz, Naresh Polisetti, Martin, Gottfried, Günther Schlunck, Ulrich, Eva, Schlötzer-Schrehardt, Ursula, Mateusz Glegola, Thomas Reinhard   +13 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Plant Secondary metabolites production by in vitro culture

Biotecnología Vegetal, 2011
Plant cell and tissue cultures are considered as an alternative source to the whole plant for the production of valuable compounds. Undifferentiated cell cultures have been extensively studied, but a large interest has also been shown in hairy roots and ...
Naivy Pérez-Alonso, Elio Jiménez
doaj