Results 101 to 110 of about 1,435,862 (389)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Short-term impact of introducing a soft opt-out organ donation system in Wales: before and after study

BMJ Open, 2019
Objectives To determine the short-term impact of a soft opt-out organ donation system on consent rates and donor numbers. Design Before and after observational study using bespoke routinely collected data.
J. Noyes, Leah Mclaughlin, K. Morgan, P. Walton, R. Curtis, S. Madden, Abigail Roberts, Michael Stephens   +7 more
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Modifiable factors influencing parental decision making and organ donation: A scoping review [PDF]

, 2017
A global shortage of organs from children and adults available for transplantation is compounded by the failure of next of the kin to consent for organs to be donated after death.
Academy of Medical Royal Colleges, Academy of Medical Royal Colleges, Nursing and Midwifery Council, Royal College of Paediatrics and Child Health   +3 more
core   +1 more source

TO SOME ORGANIZATIONAL ASPECTS OF ORGAN DONATION

Вестник трансплантологии и искусственных органов, 2010
Organization of organ donation for transplantation is one of the most actual problems of Russian Transplantolo- gy. Organ shortage for transplantation is perceiving in Russia through the improvement of organizational system of organ donation. An analysis
M. Minina
doaj   +1 more source

Knowledge and Willingness for Organ Donation in the Middle Eastern Region: A Meta-analysis

Journal of religion and health, 2019
Medical advancements over the past decades brought organ transplantation as a definitive therapy for different end-stage organ failure. However, non-availability of organs required for transplantation is a major challenge worldwide. We aimed to determine
Ahammed A Mekkodathil, A. El-Menyar, B. Sathian, Rajvir Singh, H. Al-Thani   +4 more
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Associations between end stage renal disease and HLA polymorphisms in the Guangxi Zhuang population

Scientific Reports
To investigate the genetic relationship between end stage renal disease (ESRD) and human leukocyte antigen (HLA) alleles in the Guangxi Zhuang population. We performed polymerase chain reaction reversed sequence-specific oligonucleotide (PCR-rSSO) in 325
Yongfeng Pei, Haibin Li, Chengxin Huang, Yinhong Qin, Xuyong Sun   +4 more
doaj   +1 more source

INFECTIONS IN THE POOL OF POTENTIAL ORGAN DONORS: IS IT ALWAYS CONTRAINDICATION TO DONATION?

Вестник трансплантологии и искусственных органов, 2011
The presence of certain infection in potential organ donors is significant problem for Russian Transplantology. The increase in detection of donor’s infections could be due to increase in general donor’s pool and also to utili- zation of modern ...
M. G. Minina
doaj   +1 more source