Results 91 to 100 of about 49,997 (313)

Risk factors of delayed kidney graft function following donation after circulatory death – a retrospective cohort study of Swiss kidney transplants

Swiss Medical Weekly
AIMS OF THE STUDY: On 1 September 2011, donation after circulatory death (DCD) organ donation resumed in Switzerland after the DCD programme had been suspended for four years due to jurisdictional and medico-ethical discrepancies.
Maurice Bischof, Simon Schwab, Julius Weiss, Franziska Beyeler, Christian Brunner, Sabine Camenisch, Raphaël Giraud, Yvonne Hilpertshauser, Matthias Peter Hilty, Marco Rusca, Kai Tisljar, Thomas Müller, Franz Immer   +12 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Determinants of the Willingness to be an Organ Donor [PDF]

The total value of life lost due to death because of waiting for an organ transplant is greater than $4 billion annually in the United States, and the excess demand for organs has been increasing over time.
Erdal Tekin, Naci Mocan
core  

Psychosocial Evaluation of Prospective Living Kidney Donors in Qatar: A Profile of Prospective Donors, Process, and Outcomes

Transplantation Direct
Background. In Qatar, the Committee for Oversight of Living Donation (COLD) was established at Hamad Medical Corporation in 2014 to provide standardized, multidisciplinary psychosocial evaluation (PE) for prospective living kidney donors (PLKDs) and ...
Riadh A. S. Fadhil, MD, Asma Al Abdulghani, MBBS, MS, Majid Alabdulla, MD, ABPsych, Nighat A. Ajmal, MD, ABPsych, Nicoleta R. Stanciu, BSN, Sabera I. Baqi, BSN, Pratibha Ratheesh, PhD, Dominique E. Martin, PhD   +7 more
doaj   +1 more source

The Organ Donation Conundrum

Progress in Transplantation, 2012
A discrepancy exists between the demand for and the availability of solid organs for transplant. Barriers to organ donation can be encountered at 2 key points: (1) when trying to increase the number of people willing to become organ donors and registering their intent and (2) at the time of organ procurement.
Conor, Gilligan, Sanson-Fisher, Robert William, Turon, Heidi   +2 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Optimizing Organ Donation After Euthanasia: A Critical Appraisal

This Critical Appraisal aims to explore the pharmacokinetics and pharmacodynamics of medications used in organ donors after euthanasia (ODE) and their impact on abdominal organ quality.
H. D. Lam, A. E. Braat, E. A. J. Alkemade, B. J. C. Hendriks, M. J. Coenraad, A. G. Baranski, I. P. J. Alwayn   +6 more
core   +1 more source

The Influence of Race on Approaching Families for Organ Donation and Their Decision to Donate

, 1999
OBJECTIVES: This study examined whether patients' race was associated with their families' being approached for organ donation and agreeing to donation.
McNamara, Patrick, Gudagnoli, Edward, Beasley, Carol, Evanisko, Michael J., Guadagnoli, Edward, Callender, Clive O., Poretsky, Andrea   +6 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source