Results 101 to 110 of about 143,457 (296)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Association between nonalcoholic fatty liver disease and increased glucose-to-albumin ratio in adults without diabetes

Frontiers in Endocrinology
BackgroundNonalcoholic fatty liver disease (NAFLD) affects approximately 30% of individuals globally. Both serum glucose and albumin were demonstrated to be potential markers for the development of NAFLD.
Shuai Wang, Shuai Wang, Shuai Wang, Xiaohong Lin, Chuchen Zhu, Chuchen Zhu, Chuchen Zhu, Yuqi Dong, Yuqi Dong, Yuqi Dong, Yiwen Guo, Yiwen Guo, Yiwen Guo, Zhonghao Xie, Zhonghao Xie, Zhonghao Xie, Xiaoshun He, Xiaoshun He, Xiaoshun He, Weiqiang Ju, Weiqiang Ju, Weiqiang Ju, Maogen Chen, Maogen Chen, Maogen Chen   +24 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPORTANCE OF ORGANIZATIONAL FACTORS IN OVERCOMING THE SHORTAGE OF DONOR ORGANS

Вестник трансплантологии и искусственных органов, 2011
This review highlights the main problem in organ donation practice. There was done the analysis of main orga- nizational solutions and best organ donation policy practices with accent on Spain Model of organ donation, and the comparing U.S.
I. V. Loginov, N. V. Kechaeva, O. N. Reznik   +2 more
doaj   +1 more source

Organ Quality as a Complicating Factor in Proposed Systems of Inducements for Organ Donation [PDF]

, 2010
En typisk funktion på startsidan till många webbportaler är den webbdel som presenterar exempelvis desenaste blogginläggen, nyheterna eller händelserna som har lagts till på webbplatsen. Dessa funktioner ärkända som aggreggeringswebbdelar.
Volk, Michael L.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Organ donation. [PDF]

BMJ, 1990
openaire   +3 more sources

Is Donor Age an Important Factor in Cadaveric Organ Donation?

İstanbul Medical Journal, 2018
Introduction: Our liver transplantion center has determined that the organ donation rate is low in young donors. The goal of study was to investigate whether this observation was valid and the causes for rejecting organ donation among family members of ...
Halit Ziya Dündar, Rafet Oflaz, Yavuz Selim Çınar, Pınar Sarkut, Ömer Faruk Özkan, Ekrem Kaya   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source