Results 111 to 120 of about 1,426,376 (405)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Associations between end stage renal disease and HLA polymorphisms in the Guangxi Zhuang population

Scientific Reports
To investigate the genetic relationship between end stage renal disease (ESRD) and human leukocyte antigen (HLA) alleles in the Guangxi Zhuang population. We performed polymerase chain reaction reversed sequence-specific oligonucleotide (PCR-rSSO) in 325
Yongfeng Pei, Haibin Li, Chengxin Huang, Yinhong Qin, Xuyong Sun   +4 more
doaj   +1 more source

Network meta-analysis of pharmacological treatment for antibody-mediated rejection after organ transplantation

Frontiers in Immunology
ObjectiveThis study aims to assess the efficacy of pharmacological interventions in mitigating graft injury in transplant patients with antibody-mediated rejection (AMR) through a network meta-analysis (NMA).MethodsA search was conducted on databases ...
Junjie Sun, Yanqing Yu, Fu Huang, Fu Huang, Qiuwen Zhang, Lirong Zhu, Guining He, Haibin Li, Xuyong Sun   +8 more
doaj   +1 more source

INFECTIONS IN THE POOL OF POTENTIAL ORGAN DONORS: IS IT ALWAYS CONTRAINDICATION TO DONATION?

Вестник трансплантологии и искусственных органов, 2011
The presence of certain infection in potential organ donors is significant problem for Russian Transplantology. The increase in detection of donor’s infections could be due to increase in general donor’s pool and also to utili- zation of modern ...
M. G. Minina
doaj   +1 more source

Peculiarities of the morphology of liver biopsy samples of donors above 60 years of age

Вестник трансплантологии и искусственных органов, 2020
Objective: to study the differences in the frequency of pathological processes in liver biopsy samples of donors older than 60 years (group 1) and donors currently recognized as “standard” by age – 60 years and younger (group 2). Material and methods. Of
I. M. Iljinsky, N. P. Mozheyko, D. V. Voronov, M. G. Minina, O. M. Tsirulnikova   +4 more
doaj   +1 more source

(Re)constituer un espace public et promouvoir le débat sans prendre position [PDF]

, 2013
This paper presents the analysis of a website created in 2011 by the Federal Office of Public Health (FOPH) to support an information campaign about the organ donation.
Merminod, G.
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Liver Procurement for Orthotopic Transplantation: An Analysis of the Pittsburgh Experience [PDF]

, 1984
The incidence of prospective organ donors in the United States and the techniques which are to used to guarantee their optimal use after identification are analyzed.
Abram, Barb, Cooper, Council on Scientific Affairs of the American Medical Association., Gallup, Kaufman, Shaw   +6 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Advance directives and consent to organ donation in seven university hospitals in North Rhine–Westphalia [PDF]

, 2023
Jan Sönke Englbrecht, Daniel Schrader, Holger Kraus, Melanie Schäfer, Dirk Schedler, Friedhelm Bach, Martin Söhle   +6 more
openalex   +1 more source