Results 41 to 50 of about 493,617 (211)

Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis

Vaccines, 2022
Solid organ transplant recipients were demonstrated to have reduced antibody response to the first and second doses of the COVID-19 mRNA vaccine.
Orly Efros, Roi Anteby, Mirit Halfon, Eshcar Meisel, Eyal Klang, Shelly Soffer   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Monte Carlo quantification of organ doses and risks in chest X-ray projections

Advances in Biomedical and Health Sciences
Background: X-ray imaging is a pivotal diagnostic tool that poses health risks from absorbed radiation doses. This study aimed to determine the variation in the effective dose between posterior–anterior (PA) and anterior–posterior (AP) projections and ...
Hussein M. Elmehdi, Krithikadevi Ramachandran, Mohamed M. Abuzaid, Wiam Elshami   +3 more
doaj   +1 more source

In-house-developed phantoms for organ dose measurements using bovine tissues: A comparison study with CT-Expo simulation software

Journal of Radiation and Cancer Research, 2019
Background: Estimating organ dose from computed tomography (CT) procedures is still ongoing. The aim is to reduce induced cancer risk associated with over dose.
Michael Onoriode Akpochafor, Akintayo Daniel Omojola, Rachel Ibhade Obed, Samuel Olaolu Adeneye, Oluwadare Joseph Adewa, Mary-Ann Etim Ekpo   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Radiation Dose Assessment in Diagnostic Imaging Using Thermoluminescent Dosimeter-100H Dosimeters and a RANDO Phantom: Insights from Chest, Pelvic, and Skull Examinations

Journal of Medical Physics
Purpose: This study aims to evaluate radiation doses to the skin, pelvis, and skull during routine radiographic imaging procedures. Materials and Methods: Entrance skin dose (ESD) was assessed using both direct and indirect methods.
Sedigheh Sina, Shima Alizadeh, Sadegh Abbasipour, Mozhgan Dalir, Mohaddeseh Heydarinia, Fatemeh Norouzalizadeh, Mobarakeh Nasiri, Mohammad Hossein Sadeghi, Kazem Sadeghi Ebrahim Mohammadi, Elnaz Saeedian, Minoo Shakerian, Mahboobeh Sheiki   +11 more
doaj   +1 more source

Automated and robust organ segmentation for 3D-based internal dose calculation

EJNMMI Research, 2021
Purpose In this work, we address image segmentation in the scope of dosimetry using deep learning and make three main contributions: (a) to extend and optimize the architecture of an existing convolutional neural network (CNN) in order to obtain a fast ...
Mahmood Nazari, Luis David Jiménez-Franco, Michael Schroeder, Andreas Kluge, Marcus Bronzel, Sharok Kimiaei   +5 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source