Results 161 to 170 of about 1,992,155 (390)

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier   +8 more
wiley   +1 more source

A Survey on Structure-Preserving Graph Transformers [PDF]

open access: yesarXiv
The transformer architecture has shown remarkable success in various domains, such as natural language processing and computer vision. When it comes to graph learning, transformers are required not only to capture the interactions between pairs of nodes but also to preserve graph structures connoting the underlying relations and proximity between them,
arxiv  

Elucidating the Supramolecular Interaction of Positively Supercharged Fluorescent Protein with Anionic Phthalocyanines

open access: yesAdvanced Biology, Volume 9, Issue 5, May 2025.
Positively supercharged mGreenLatern protein is self‐assembled electrostatically with negatively charged zinc phthalocyanines to yield bio‐based photoactive materials in aqueous media. The addition of phthalocyanines results in the formation of large complexes fully quenching of the protein fluorescence. The results indicate an energy transfer from the
Sharon Saarinen   +10 more
wiley   +1 more source

Considering the Risks and Costs of Solid Organ Xenotransplantation

open access: yesAdvanced Biology, Volume 9, Issue 4, April 2025.
This perspective discusses the rationale, risks, and costs of whole‐organ xenotransplantation. It considers alternative strategies to obviate the demand for transplants and optimize allotransplantation systems and practices that do not impose xenotransplantation's harms and risks, and whether they are the most ethical and effective means to increase ...
Catharine E. Krebs   +5 more
wiley   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

open access: yesAdvanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav   +5 more
wiley   +1 more source

Domain Adaptation for Sustainable Soil Management using Causal and Contrastive Constraint Minimization [PDF]

open access: yesarXiv
Monitoring organic matter is pivotal for maintaining soil health and can help inform sustainable soil management practices. While sensor-based soil information offers higher-fidelity and reliable insights into organic matter changes, sampling and measuring sensor data is cost-prohibitive.
arxiv  

Optimal strategies for prevention of ischemia‑reperfusion injury in heart transplantation with prolonged cold ischemia time (review)

open access: yesВестник трансплантологии и искусственных органов
The shortage of organs for transplant remains a major challenge in transplantology. Transporting donor organs over long distances increases cold ischemia time, which is a risk factor for ischemia-reperfusion injury (IRI).
A. V. Fomichev   +12 more
doaj   +1 more source

Rheologic considerations in organ preservation [PDF]

open access: bronze, 2000
Edward M. Boyle, Edward D. Verrier
openalex   +1 more source

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