Results 61 to 70 of about 119,972 (311)

The novel compound PICCS improves cell viability during cold storage and reduces pulmonary ischemia-reperfusion injury in a rat model

Scientific Reports
A simple method to achieve better organ preservation is the addition of compounds to the preservation solution, which effectively inhibits cold injury.
Yuhei Yokoyama, Masayasu Toyomoto, Nobuo Tanaka, Satona Tanaka, Shigeto Nishikawa, Hidenao Kayawake, Yuki Morimura, Hiromi Oda, Momono Yamauchi, Makoto Yamamoto, Toyofumi F. Chen-Yoshikawa, Masatoshi Hagiwara, Hiroshi Date   +12 more
doaj   +1 more source

Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model

Asian Journal of Surgery, 2017
Background/Objective: Currently, due to lack of optimal donors, more marginal organs are transplanted. Therefore, there is a high interest to ameliorate preischemic organ preservation, especially for critical donor organs. In this regard, a new histidine-
Mohammad Golriz, Hamidreza Fonouni, Gani Kuttymuratov, Majid Esmaeilzadeh, Morva Tahmasbi Rad, Parvin Jarahian, Thomas Longerich, Alireza Faridar, Sepehr Abbasi, Arianeb Mehrabi, Marta M. Gebhard   +10 more
doaj   +1 more source

Taurine as Antioxidant in a Novel Cell- and Oxygen Carrier-Free Perfusate for Normothermic Machine Perfusion of Porcine Kidneys

Antioxidants, 2023
Donor organ-shortage has resulted in the increased use of marginal grafts; however, normothermic machine perfusion (NMP) holds the potential for organ viability assessment and restoration of marginal grafts prior to transplantation.
Laura Zarnitz, Benedict M. Doorschodt, Lisa Ernst, Aisa Hosseinnejad, Eileen Edgworth, Tamara Fechter, Alexander Theißen, Sonja Djudjaj, Peter Boor, Rolf Rossaint, René H. Tolba, Christian Bleilevens   +11 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

MitoQ blunts mitochondrial and renal damage during cold preservation of porcine kidneys. [PDF]

PLoS ONE, 2012
Cold preservation has greatly facilitated the use of cadaveric kidneys for transplantation but damage occurs during the preservation episode. It is well established that oxidant production increases during cold renal preservation and mitochondria are a ...
Nirmala Parajuli, Lia H Campbell, Akira Marine, Kelvin G M Brockbank, Lee Ann Macmillan-Crow   +4 more
doaj   +1 more source

Does an Additional Bile Duct Flush With Low-viscosity Preservation Solution Reduce Bile Duct Injury? A Single-blinded Randomized Clinical Trial

Transplantation Direct, 2023
Introduction. Biliary complications are a common cause of morbidity after liver transplantation and associated with bile duct injury. To reduce injury, a bile duct flush is performed with high-viscosity preservation solution.
Mark Ly, BMed, MS, Ngee-Soon Lau, MD, FRACS, Catriona McKenzie, MBBS, FRCPA, James G. Kench, MBBS, FRCPA, Geoffrey McCaughan, MBBS, PhD, FRACP, Michael Crawford, MBBS, MMed, FRACS, Carlo Pulitano, MD, PhD, FRACS   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Organ preservation solutions

Ejhp practice, 2009
Systematic research has led to continuing improvements in the solutions and techniques of preserving donated hearts. The persistent shortage of donors means that organs of lower quality are increasingly being accepted and we are turning more and more to machine perfusion of donated hearts.
Leuvenink, H, Ploeg, R
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Effect of PERLA®, a new cold-storage solution, on oxidative stress injury and early graft function in rat kidney transplantation model

BMC Nephrology
Background The composition of organ preservation solutions is crucial for maintaining graft integrity and early graft function after transplantation.
Mohamed Bejaoui, Chérifa Slim, Carmen Peralta, Hassen Ben Abdennebi   +3 more
doaj   +1 more source