Results 111 to 120 of about 13,374,903 (323)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression

open access: yesNature Communications, 2016
The hormone Dipl8 regulates organ growth inDrosophila whereas the Hippo pathway controls organ size. Here, the authors show that the expression of Dipl8 is regulated by the Hippo pathway, thus linking organ growth or organ size in Drosophila.
Emilie Boone   +3 more
doaj   +1 more source

The Relation between Body Size and Organ Size in Plants [PDF]

open access: yesThe American Naturalist, 1921
1. The problem of the relationship between the size of the plant body and the size of the organs it produces has been studied by various workers, who find that in most cases there is a small but significant correlation between these characters. 2.
openaire   +1 more source

Attitudes towards organ donation in Malta in the last decade [PDF]

open access: yes, 2006
Organ transplantation is possibly one of the few cases when even though the medical professionals have the expertise to carry out transplants of certain organs, and even though a person may have financial resources to cover every possible cost, the ...
Lauri, Mary Anne
core  

Size- and Dose-Dependent Body-Wide Organ Transcriptomic Responses to Calcium Phosphate Nanomaterials

open access: yes, 2023
Nanomaterials are widely used in clinical practice. There are potential risks of body-wide infiltration due to their small size; however, the body-wide reliable risk assessment of nanoparticle infiltration is not fully studied and established.
Junwen Zhang (833829)   +15 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.

open access: yesGenes & Development, 2010
The Hippo signaling pathway is gaining recognition as an important player in both organ size control and tumorigenesis, which are physiological and pathological processes that share common cellular signaling mechanisms. Upon activation by stimuli such as
Bin Zhao, Li Li, Qun-Ying Lei, K. Guan
semanticscholar   +1 more source

ADMINISTRATION SIZE AND ORGANIZATION SIZE: AN EXAMINATION OF THE LAG STRUCTURE.

open access: yesAcademy of Management Journal, 1984
The article provides information on a study pertaining to the lag structure in the relationship between organization size and administration size.
Cullen, John B., Baker, Douglas D.
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

When are bereaved family members approached for consent to organ donation? Commentary from 10 European member states [PDF]

open access: yes, 2014
Background - To scope the timing of the approach to bereaved family members and request for organ donation in DBD and DCD potential donors, in 10 European member states. Are there changes in established practice regarding when family members are asked to
Long-Sutehall, Tracy   +4 more
core   +2 more sources

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