Results 131 to 140 of about 1,576,029 (286)
The ORGAN SIZE (ORG) locus modulates both vegetative and reproductive gigantism in domesticated tomato. [PDF]
Ann Bot, 2023 Vicente MH +10 more
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
The Relationship of the Lower Ribcage with Liver and Gut Size: Implications for Paleoanthropology
HumansOrgan–skeleton relationships are understudied in biological anthropology. The torso skeleton is often used to infer the organ size and evolution in hominins; ribcage “types”, in particular, are used to infer the abdominal organ size in hominins.
Jeanelle Uy +2 more
doaj +1 more source
The WIGGUM gene is required for proper regulation of floral meristem size in Arabidopsis [PDF]
, 1998 The study of cell division control within developing tissues is central to understanding the processes of pattern formation. The floral meristem of angiosperms gives rise to floral organs in a particular number and pattern.
Fletcher, Jennifer C. +2 more
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Genome-wide analysis of KIX gene family for organ size regulation in soybean (Glycine max L.). [PDF]
Front Plant Sci, 2023 Park GT +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
High‐Speed Embedded Ink Writing of Anatomic‐Size Organ Constructs
Advanced ScienceEmbedded ink writing (EIW) is an emerging 3D printing technique that fabricates complex 3D structures from various biomaterial inks but is limited to a printing speed of ∼10 mm s−1 due to suboptimal rheological properties of particulate‐dominated yield ...
Weijian Hua +17 more
doaj +1 more source