Results 91 to 100 of about 746,994 (292)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Organ Size: The Role of Mobile Signals [PDF]
Current Biology, 2010 SummaryWhat controls where, how fast and how long an organ will grow? A mobile signal regulated by a plant cytochrome P450 provides a new piece to the puzzle.
openaire +2 more sources
Control of growth and organ size in Drosophila.
, 2002 Transplantation experiments have shown that developing metazoan organs carry intrinsic information about their size and shape. Organ and body size are also sensitive to extrinsic cues provided by the environment, such as the availability of nutrients ...
Johnston, L A +5 more
core +1 more source
, 2014 PurposeAAPM Task Group 204 introduced size-specific dose estimates for pediatric and adult patients undergoing body CT examinations. This investigation extends that work to head CT exams by using Monte Carlo simulations to develop size-specific, scanner ...
Zankl, Maria +11 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Non-cell-autonomously coordinated organ size regulation in leaf development
, 2010 The way in which the number and size of cells in an organ are determined poses a central challenge in our understanding of organ size control. Compensation is an unresolved phenomenon, whereby a decrease in cell proliferation below some threshold level ...
Kensuke Kawade +2 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Organ size determination and the limits of regulation [PDF]
Cell Cycle, 2008 The size of an organism dictates both its functional challenges and how it meets them. Despite being a universal feature of all living creatures, how an organism determines its size, and that of its internal organs, is largely unknown. In particular, the mechanisms by which organs sense magnitude and alter cellular behavior to ensure symmetry ...
openaire +2 more sources
The E3 Ubiquitin Ligase BIG BROTHER Controls Arabidopsis Organ Size in a Dosage-Dependent Manner
, 2006 SummaryOrgan growth up to a species-specific size is tightly regulated in plants and animals [1, 2]. Final organ size is remarkably constant within a given species, suggesting that a species-specific size checkpoint terminates organ growth in a ...
Lenhard, Michael +5 more
core +1 more source
Epithelial to mesenchymal transition in breast cancer : a novel murine model system and the regulatory role of tead transcription factors [PDF]
, 2012 Cancer is a leading cause of death worldwide, accounting for 7.6 million, or ~13% of all deaths in 2008. The majority of cancers arise from epithelia. Breast cancer, originating from the mammary epithelium, is the most frequent cancer in women worldwide.
Waldmeier, Lorenz
core +1 more source