Results 81 to 90 of about 13,374,903 (323)
Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis
Gastroenterology, 2016 The Hippo signaling pathway, also known as the Salvador–Warts–Hippo pathway, is a regulator of organ size. The pathway takes its name from the Drosophila protein kinase, Hippo (STK4/MST1 and STK3/MST2 in mammals), which, when inactivated, leads to ...
Sachin H. Patel +2 more
semanticscholar +1 more source
Discrete hierarchical organization of social group sizes [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2005 The ‘social brain hypothesis’ for the evolution of large brains in primates has led to evidence for the coevolution of neocortical size and social group sizes, suggesting that there is a cognitive constraint on group size that depends, in some way, on the volume of neural material available for processing and synthesizing information on social ...
Zhou, W. X. +3 more
openaire +4 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Organ size regulation in plants: insights from compensation
Frontiers in Plant Science, 2011 The regulation of organ size in higher organisms is a fundamental issue in developmental biology. In flowering plants, a phenomenon called compensation has been observed where a cell proliferation defect in developing leaf primordia triggers excessive ...
Gorou eHoriguchi, Hirokazu eTsukaya
doaj +1 more source
Developmental Cell, 2017 Summary The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined.
Peng Zhang +11 more
semanticscholar +1 more source
The pipe organ in twentieth-century Great Britain, with specific focus on the development and effects of the neo-classical organ [PDF]
, 2004 From as early as the 1920s the romantic English organ became the target of much criticism, specifically amongst Europeans. Albert Schweitzer, for example, had questioned the organ's suitability for the performance of Bach's organ works, deploring its ...
Atherton, Matthew Stuart
core
An international comparison of deceased and living organ donation/transplant rates in opt-in and opt-out systems: a panel study [PDF]
, 2014 Background: Policy decisions about opt-in and opt-out consent for organ donation are based on limited evidence. To fill this gap we investigated the difference between deceased and living organ donation rates in opt-in and opt-out consent systems across ...
Ronan E O’Carroll +6 more
core +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The sexual identity of adult intestinal stem cells controls organ size and plasticity
Nature, 2016 Sex differences in physiology and disease susceptibility are commonly attributed to developmental and/or hormonal factors, but there is increasing realization that cell-intrinsic mechanisms play important and persistent roles.
Bruno Hudry +2 more
semanticscholar +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source