Results 71 to 80 of about 746,994 (292)

YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells

, 2007
SummaryThe mechanisms that regulate mammalian organ size are poorly understood. It is unclear whether the pathways that control organ size also impinge on stem/progenitor cells.
Fernando D. Camargo, Dongdong Fu, Gokhale, Sumita, Sumita Gokhale, Bell, George W., George W. Bell, Thijn R. Brummelkamp, Fu, Dongdong, Camargo, Fernando D., Rudolf Jaenisch, Johnnidis, Jonathan B., Brummelkamp, Thijn R., Jaenisch, Rudolf, Jonathan B. Johnnidis   +13 more
core   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

OsGIF1 Positively Regulates the Sizes of Stems, Leaves, and Grains in Rice

Frontiers in Plant Science, 2017
Growth-regulating factor (GRF) interacting factors (GIFs) are involved in several developmental processes in Arabidopsis. We previously showed that upregulation of OsGIF1 expression improves rice grain size.
Zhongshan He, Zhongshan He, Jing Zeng, Jing Zeng, Yun Ren, Yun Ren, Dan Chen, Dan Chen, Wenjie Li, Wenjie Li, Fengyan Gao, Fengyan Gao, Ye Cao, Ye Cao, Tao Luo, Tao Luo, Guoqiang Yuan, Guoqiang Yuan, Xianghong Wu, Xianghong Wu, Yueyang Liang, Yueyang Liang, Qiming Deng, Qiming Deng, Shiquan Wang, Shiquan Wang, Aiping Zheng, Aiping Zheng, Jun Zhu, Jun Zhu, Huainian Liu, Huainian Liu, Lingxia Wang, Lingxia Wang, Ping Li, Ping Li, Ping Li, Shuangcheng Li, Shuangcheng Li   +38 more
doaj   +1 more source

Estimating Specific Patient Organ Dose for Chest CT Examinations with Monte Carlo Method

Applied Sciences, 2021
Purpose: The purpose of this study was to preliminarily estimate patient-specific organ doses in chest CT examinations for Chinese adults, and to investigate the effect of patient size on organ doses.
Yang Yang, Weihai Zhuo, Yiyang Zhao, Tianwu Xie, Chuyan Wang, Haikuan Liu   +5 more
doaj   +1 more source

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer [PDF]

, 2015
Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation ...
Yu, Fa-Xing, Guan, Kun-Liang, Zhao, Bin
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Performance, egg quality and organ traits of laying hens fed black soldier fly larvae products

Poultry Science
: Due to consumer demands and institutional pressure, the egg production sector, is looking for alternative protein sources for laying hen feed to support more sustainable, circular production.
Anna Dörper, Gerrit Gort, Jan van Harn, Dennis G.A.B. Oonincx, Marcel Dicke, Teun Veldkamp   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hippo signaling in organ size control [PDF]

Genes & Development, 2007
The control of organ (or organism) size is a fundamental aspect of life that has long captured human imagination. What makes an elephant grow a million times larger than a mouse? How do our two hands develop independently of each other yet reach very similar size? How does a liver precisely regenerate its original mass when two-thirds of it is removed?
openaire   +2 more sources