Results 51 to 60 of about 746,994 (292)

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

eLife, 2015
The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes. Understanding how this pathway is regulated in development remains a major challenge.
Hua Deng, Wei Wang, Jianzhong Yu, Yonggang Zheng, Yun Qing, Duojia Pan   +5 more
doaj   +1 more source

Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish

eLife, 2015
During development, proliferation must be tightly controlled for organs to reach their appropriate size. While the Hippo signaling pathway plays a major role in organ growth control, how it senses and responds to increased cell density is still unclear ...
Sobhika Agarwala, Sandra Duquesne, Kun Liu, Anton Boehm, Lin Grimm, Sandra Link, Sabine König, Stefan Eimer, Olaf Ronneberger, Virginie Lecaudey   +9 more
doaj   +1 more source

Evaluation of interface quality in organ-cultured lamellar corneal transplants

, 2012
Background: With increasing numbers of lamellar keratoplasties, eye banks are challenged to deliver precut lamellar donor tissue. In Europe, the most common technique of corneal storage is organ culture which requires a deswelling process before surgical
Kohnen, Thomas, Wolf, Armin, Kook, Daniel, Grüterich, Martin, Jagow, Burkhard von, Kampik, Anselm, Lackerbauer, Carlo A., Messmer, Elisabeth M.   +7 more
core   +1 more source

Ultrasonographic parameters of the liver, spleen and kidney in a healthy paediatric population in Bosnia and Herzegovina: a prospective study

Medicinski Glasnik
Aim To determine the normative range of ultrasound dimensions for the liver, spleen and kidneys in healthy children according to gender, age, body measurements, body surface area (BSA), and the influence of ethnicity on organ size.Methods The prospective
Nina Мekić, Nermin Salkić, Amela Selimović, Majda Mehmedović, Aida Brčić, Zlatan Mehmedović, Amra Šerak, Dijana Dugonjić   +7 more
doaj   +1 more source

Regulatory change at Physalis Organ Size 1 correlates to natural variation in tomatillo reproductive organ size

, 2014
The genetic basis of size variation in the reproductive organs of tomatillo (Physalis philadelphica) is unknown. Here we report that the expression levels of the gene Physalis Organ Size 1 (POS1) are positively associated with size variation in P ...
Li, Zhichao, Wang, Li, Zhao, Jing, He, Lingli, Li, Jing, He, Chaoying   +5 more
core   +1 more source

Ontogenic Caste Differences in the Van der Vecht Organ of Primitively Eusocial Neotropical Paper Wasps. [PDF]

PLoS ONE, 2016
Recent studies have reported incipient morphological caste dimorphism in the Van der Vecht organ size of some temperate Polistes paper wasps. Whether species other than the temperate ones show a similar pattern remains elusive. Here, we have studied some
André Rodrigues de Souza, Iacopo Petrocelli, José Lino-Neto, Eduardo Fernando Santos, Fernando Barbosa Noll, Stefano Turillazzi   +5 more
doaj   +1 more source

Organ Size Control by Hippo and TOR Pathways

, 2012
The determination of final organ size is a highly coordinated and complex process that relies on the precise regulation of cell number and/or cell size.
Russell, Ryan C., Guan, Kun-Liang, Tumaneng, Karen   +2 more
core   +1 more source

Altered paracrine signaling from the injured knee joint impairs postnatal long bone growth

eLife, 2017
Regulation of organ growth is a poorly understood process. In the long bones, the growth plates (GPs) drive elongation by generating a scaffold progressively replaced by bone.
Alberto Roselló-Díez, Daniel Stephen, Alexandra L Joyner   +2 more
doaj   +1 more source

Double Muscling in Cattle: Genes, Husbandry, Carcasses and Meat

Animals, 2012
Molecular biology has enabled the identification of the mechanisms whereby inactive myostatin increases skeletal muscle growth in double-muscled (DM) animals.
Leo O. Fiems
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source