Results 141 to 150 of about 2,489,307 (382)

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua   +9 more
wiley   +1 more source

Sirtuin 3 in renal diseases and aging: From mechanisms to potential therapies

open access: yesPharmacological Research
The longevity protein sirtuins (SIRTs) belong to a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases. In mammals, SIRTs comprise seven members (SIRT1–7) which are localized to different subcellular compartments.
Xuan Peng   +6 more
doaj  

Evaluating the efficacy of basiliximab versus no induction in low-immunological-risk kidney transplant recipients: a propensity score matched analysis

open access: yesRenal Failure
Background The optimal use of induction therapy in low-immunological-risk kidney transplant recipients (KTRs) remains uncertain. While Basiliximab (BSX) is widely utilized, its comparative outcomes with no induction therapy require further evaluation ...
Dahao Zhang   +10 more
doaj   +1 more source

The current status of hepatic transplantation at the University of Pittsburgh. [PDF]

open access: yes, 1995
Tacrolimus is a more potent and satisfactory immunosuppressant than CyA for combination therapy with prednisone. In randomized trials comparing the 2 drugs, the ability of tacrolimus to rescue intractably rejecting grafts on the competing CyA arm allowed
Abu-Elmagd, K   +9 more
core  

Ultra‐Tiny Gelatin Nanoparticles‐Assisted 3D Stem Cell Spheroids for Engineering Tissue Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
GNPs effectively guide the formation of structurally compact and functionally enhanced stem cell spheroids. This GNP‐assisted 3D culture system improves cell–cell and cell‐ECM interactions, leading to superior viability and complexity. Time‐dependent regenerative potential is demonstrated in both bone and skin defects, positioning GNP‐spheroids as a ...
Dream Kim   +7 more
wiley   +1 more source

MDSC suppresses T cell antitumor immunity in CAC via GPNMB in a MyD88‐dependent manner

open access: yesCancer Medicine
Background Myeloid‐derived suppressor cells (MDSCs) played an essential role in tumor microenvironment to suppress host antitumor immunity and help cancer cells escape immune surveillance. However, the molecular mechanism behind tumor evasion mediated by
Bo Wang, Lu Wang, Runshi Shang, Lin Xie
doaj   +1 more source

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