Results 151 to 160 of about 440,505 (312)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

HLA-F–Based Diagnostic Index for Kidney Transplantation: Clinical Application and Validation

International Journal of Clinical Practice
Cheng Zhang, Yijian Zhang, Jinyu Wei, Guanmiao Chen, Kun Dong, Junze Chen, Yongyuan Jian, Kaiyong Huang, Ruiling Su, Xuelin Tan, Jialing Huang, Chengyu Huang, Ke Mo, Chunqiang Dong, Boqian Wang   +14 more
doaj   +1 more source

Oncology and Solid Organ Transplantation: New Biological and Clinical Insights. [PDF]

Transpl Int
Zaza G, Weissenbacher A, Vitale A, Marson L, Line PD, Cucchiari D, Kronbichler A.   +6 more
europepmc   +1 more source

Intestinal and multiple organ transplantation [PDF]

, 2005
Abu-Elmagd, K, Mazariegos, G, Reyes, J, Starzl, TE   +3 more
core  

Body temperature changes during organ transplantation. [PDF]

, 1970
Aldrete, JA, Clapp, HW, Starzl, TE
core   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

FK506 IN CLINICAL ORGAN-TRANSPLANTATION [PDF]

, 1991
ABUELMAGD, K, ARMITAGE, J, BRONSTER, O, FUNG, JJ, GORDON, R, JAIN, A, JORDAN, M, KORMOS, R, MARTIN, M, SELBY, R, SHAPIRO, R, STARZL, TE, STIEBER, A, TODO, S, TZAKIS, A   +14 more
core  

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Microplastics in organ transplantation: An emerging threat requiring immediate action. [PDF]

World J Transplant
Emmanouilidou A, Karageorgos FF, Tsoulfas G, Alexopoulos AH.   +3 more
europepmc   +1 more source

Principles of whole organ transplantation [PDF]

, 1984
Iwatsuki, S, Shaw, BW, Starzl, TE
core