Results 161 to 170 of about 286,304 (317)

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Editorial: Innovative approaches to immunogenetics and organ transplantation. [PDF]

Front Immunol
Süsal C, Morath C.
europepmc   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Organ transplantation in Fontan patients-beware of false promises. [PDF]

JHLT Open
Sallmon L, Berlakovich GA, Kramer P, Kurath-Koller S, Laufer G, Sallmon H.   +5 more
europepmc   +1 more source

Organ Harvesting From Donor Killed By Euthanasia May Undermine Public Trust In Transplantation

, 2019
Ethical controversies in transplantation are mainly the consequence of organ shortage. Organ trading and use of organs from executed prisoners are condemned by transplant community.
Buturović-Ponikvar, Jadranka, Buturović-Bradarić, Željka   +1 more
core  

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Abdominal Organ Transplantation: Noteworthy Literature in 2025. [PDF]

Semin Cardiothorac Vasc Anesth
Katayama A, Casale M, Huseby R, Wang R, Sakai T.   +4 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

HLA-F–Based Diagnostic Index for Kidney Transplantation: Clinical Application and Validation

International Journal of Clinical Practice
Cheng Zhang, Yijian Zhang, Jinyu Wei, Guanmiao Chen, Kun Dong, Junze Chen, Yongyuan Jian, Kaiyong Huang, Ruiling Su, Xuelin Tan, Jialing Huang, Chengyu Huang, Ke Mo, Chunqiang Dong, Boqian Wang   +14 more
doaj   +1 more source

Immuno-imaging in solid organ transplantation. [PDF]

Am J Transplant
Maas RJF, Versteeg I, de Jong LC, Fayad Z, Aarntzen EHJG, Mulder WJM, Teunissen AJP, Duivenvoorden R.   +7 more
europepmc   +1 more source