Results 1 to 10 of about 1,088,075 (297)

The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses

Cell Reports, 2017
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored.
Michihiro Takahama, Mitsunori Fukuda, Norihiko Ohbayashi, Tatsuya Kozaki, Takuma Misawa, Toru Okamoto, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh   +8 more
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Host upregulation of lipid droplets drives antiviral responses

Cell Stress, 2021
When a host cell is infected by a virus, it activates the innate immune response, setting off a cascade of signalling events leading to the production of an antiviral response.
Ebony A. Monson, Karla J. Helbig
doaj   +1 more source

Recent developments in mitochondrial medicine (Part 1)

4 open, 2021
Research into elucidating structure and function of mitochondria has been quite steady between the time of discovery during the end of the 19th century until towards the late 1980’s.
Weissig Volkmar, Edeas Marvin
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Mechanisms of Non-Vesicular Exchange of Lipids at Membrane Contact Sites: Of Shuttles, Tunnels and, Funnels

Frontiers in Cell and Developmental Biology, 2021
Eukaryotic cells are characterized by their exquisite compartmentalization resulting from a cornucopia of membrane-bound organelles. Each of these compartments hosts a flurry of biochemical reactions and supports biological functions such as genome ...
Pascal F. Egea
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Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids

Frontiers in Cell and Developmental Biology, 2020
Luminal pH and the distinctive distribution of phosphatidylinositol phosphate (PIP) lipids are central identifying features of organelles in all eukaryotic cells that are also critical for organelle function.
Subhrajit Banerjee, Patricia M. Kane
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Quantifying compartment‐associated variations of protein abundance in proteomics data

Molecular Systems Biology, 2018
Quantitative mass spectrometry enables to monitor the abundance of thousands of proteins across biological conditions. Currently, most data analysis approaches rely on the assumption that the majority of the observed proteins remain unchanged across ...
Luca Parca, Martin Beck, Peer Bork, Alessandro Ori   +3 more
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Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol

Nature Communications
Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived DNA in the cytosol. STING may function as a scaffold to activate TANK-binding kinase 1 (TBK1), but direct cellular evidence remains lacking.
Haruka Kemmoku, Kanoko Takahashi, Kojiro Mukai, Toshiki Mori, Koichiro M. Hirosawa, Fumika Kiku, Yasunori Uchida, Yoshihiko Kuchitsu, Yu Nishioka, Masaaki Sawa, Takuma Kishimoto, Kazuma Tanaka, Yasunari Yokota, Hiroyuki Arai, Kenichi G. N. Suzuki, Tomohiko Taguchi   +15 more
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Chemo‐small extracellular vesicles released in cisplatin‐resistance ovarian cancer cells are regulated by the lysosomal function

Journal of Extracellular Biology
Chemoresistance is a common problem in ovarian cancer (OvCa) treatment, where resistant cells, in response to chemotherapy, secrete small extracellular vesicles (sEVs), known as chemo‐sEVs, that transfer resistance to recipient cells.
Cristóbal Cerda‐Troncoso, Felipe Grünenwald, Eloísa Arias‐Muñoz, Viviana A. Cavieres, Albano Caceres‐Verschae, Sergio Hernández, Belén Gaete‐Ramírez, Francisca Álvarez‐Astudillo, Rodrigo A. Acuña, Matias Ostrowski, Patricia V. Burgos, Manuel Varas‐Godoy   +11 more
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Emerging magic bullet: subcellular organelle-targeted cancer therapy

Medical Review
The therapeutic efficacy of anticancer drugs heavily relies on their concentration and retention at the corresponding target site. Hence, merely increasing the cellular concentration of drugs is insufficient to achieve satisfactory therapeutic outcomes ...
Yan Yue, Zhang Yimeng, Liu Jianxiong, Chen Binlong, Wang Yiguang   +4 more
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CHIP as a membrane-shuttling proteostasis sensor

eLife, 2017
Cells respond to protein misfolding and aggregation in the cytosol by adjusting gene transcription and a number of post-transcriptional processes. In parallel to functional reactions, cellular structure changes as well; however, the mechanisms underlying
Yannick Kopp, Wei-Han Lang, Tobias B Schuster, Adrián Martínez-Limón, Harald F Hofbauer, Robert Ernst, Giulia Calloni, R Martin Vabulas   +7 more
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