Results 111 to 120 of about 463,135 (398)

Single organelle function and organization as estimated from Arabidopsis mitochondrial proteomics.

The Plant Journal, 2019
Mitochondria host vital cellular functions, including oxidative phosphorylation and co-factor biosynthesis, which are reflected in their proteome. At the cellular level plant mitochondria are organized into hundreds of discrete functional entities, which
Philippe Fuchs, Nils Rugen, Chris Carrie, Marlene Elsässer, I. Finkemeier, Jonas Giese, Tatjana M. Hildebrandt, Kristina Kühn, V. Maurino, Cristina Ruberti, Mareike Schallenberg-Rüdinger, Janina Steinbeck, H. Braun, Holger Eubel, E. Meyer, Stefanie J. Müller-Schüssele, M. Schwarzländer   +16 more
semanticscholar   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Inter-organelle membrane contact sites: implications for lipid metabolism

Biology Direct, 2020
This article supplements a recent Perspective by Scorrano et al. in Nature Communications [10 [ (1)]:1287] in which the properties and functions of inter-organelle membrane contact sites were summarized.
J. Vance
semanticscholar   +1 more source

Organelles in parallel [PDF]

The Journal of Cell Biology, 2008
Endocytic organelles in three eukaryotic kingdoms evolved in parallel, according to Joel Dacks, Mark Field (University of Cambridge, UK), and Pak Poon (Dalhousie University, Halifax, Canada). Unlike mitochondria and chloroplasts, the membrane trafficking system did not arise through endosymbiosis; it evolved from within.
openaire   +2 more sources

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol

Nature Communications
Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived DNA in the cytosol. STING may function as a scaffold to activate TANK-binding kinase 1 (TBK1), but direct cellular evidence remains lacking.
Haruka Kemmoku, Kanoko Takahashi, Kojiro Mukai, Toshiki Mori, Koichiro M. Hirosawa, Fumika Kiku, Yasunori Uchida, Yoshihiko Kuchitsu, Yu Nishioka, Masaaki Sawa, Takuma Kishimoto, Kazuma Tanaka, Yasunari Yokota, Hiroyuki Arai, Kenichi G. N. Suzuki, Tomohiko Taguchi   +15 more
doaj   +1 more source

Acute Pancreatitis: A Multifaceted Set of Organelle and Cellular Interactions.

Gastroenterology, 2019
Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with tissue injury and necrosis. The disease can be mild, involving only the pancreas, and resolve spontaneously within days or severe, with systemic inflammatory response
Aida Habtezion, A. Gukovskaya, S. Pandol
semanticscholar   +1 more source

Assembly of the algal CO2-fixing organelle, the pyrenoid, is guided by a Rubisco-binding motif

Science Advances, 2020
A protein motif mediates targeting of proteins to the pyrenoid and appears to link the pyrenoid’s three subcompartments. Approximately one-third of the Earth’s photosynthetic CO2 assimilation occurs in a pyrenoid, an organelle containing the CO2-fixing ...
Moritz T. Meyer, Alan K. Itakura, Weronika Patena, Lian-li Wang, Shan He, Tom Z. Emrich-Mills, C. S. Lau, G. Yates, L. Mackinder, M. Jonikas   +9 more
semanticscholar   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

Chemo‐small extracellular vesicles released in cisplatin‐resistance ovarian cancer cells are regulated by the lysosomal function

Journal of Extracellular Biology
Chemoresistance is a common problem in ovarian cancer (OvCa) treatment, where resistant cells, in response to chemotherapy, secrete small extracellular vesicles (sEVs), known as chemo‐sEVs, that transfer resistance to recipient cells.
Cristóbal Cerda‐Troncoso, Felipe Grünenwald, Eloísa Arias‐Muñoz, Viviana A. Cavieres, Albano Caceres‐Verschae, Sergio Hernández, Belén Gaete‐Ramírez, Francisca Álvarez‐Astudillo, Rodrigo A. Acuña, Matias Ostrowski, Patricia V. Burgos, Manuel Varas‐Godoy   +11 more
doaj   +1 more source