Results 171 to 180 of about 1,118,522 (291)

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

VARIDT 4.0: distribution variability of drug transporters. [PDF]

Nucleic Acids Res
Li Y, Yang F, Pan Z, Yan Y, Jiang B, Huang X, Wang H, Qin X, Yin J, Zeng S, Fu T, Zhu F.   +11 more
europepmc   +1 more source

Correction: Visualizing the dynamic polymerization of the bacterial actin-like cytoskeleton for magnetic organelle positioning [PDF]

Yuanyuan Pan, Yousuke Kikuchi, Takumi Saito, Yoshihiro FUKUMORI, Azuma Taoka   +4 more
openalex   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Species-specific marker development for accurate identification of three red algae (<i>Grateloupia asiatica</i>, <i>Pachymeniopsis lanceolata</i> and <i>Polyopes affinis</i>) based on complete organelle genomes. [PDF]

Mar Life Sci Technol
Lee YJ, Kim YM, Kim CM, Choi SJ, Jang CS.   +4 more
europepmc   +1 more source

Formation of organelle-like N ₂ -fixing symbiosomes in legume root nodules is controlled by DMI2

, 2005
Erik Limpens, Rossana Mirabella, Elena Fedorova, Carolien Franken, Henk Franssen, Ton Bisseling, René Geurts   +6 more
openalex   +2 more sources

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

A morphology-based machine learning model for scoring epithelial-mesenchymal plasticity using organelle dynamics. [PDF]

Commun Biol
Slager J, Gatto F, Frey B, Shi W, Porebski B, Carreras-Puigvert J, Parniewska MM, Fuxe J.   +7 more
europepmc   +1 more source

A Chromosome-Level Genome Assembly of the European Beech (Fagus sylvatica) Reveals Anomalies for Organelle DNA Integration, Repeat Content and Distribution of SNPs

, 2022
Bagdevi Mishra, Bartosz Ulaszewski, Joanna Meger, Jean‐Marc Aury, Catherine Bodénès, Isabelle Lesur‐Kupin, Markus Pfenninger, Corinne Da Silva, Deepak Gupta, Erwan Guichoux, Katrin Heer, Céline Lalanne, Karine Labadie, Lars Opgenoorth, Sebastian Ploch, Grégoire Le Provost, Jérôme Salse, Ivan Scotti, Stefan Wötzel, Christophe Plomion, Jarosław Burczyk, Marco Thines   +21 more
openalex   +1 more source

Organelle [PDF]

, 2019
openaire   +1 more source