Results 241 to 250 of about 1,118,522 (291)

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Unraveling the role of distinct cytoskeletal motility structures in Mycoplasma pneumoniae relatives. [PDF]

BMC Microbiol
Chen J, Jiang Y, Wang Y, Zeng G, Liu P, She J, Zhong K, Duan B, Huang H, Wen Y, Chen W.   +10 more
europepmc   +1 more source

The neuronal cilium – a highly diverse and dynamic organelle involved in sensory detection and neuromodulation

Nathalie Jurisch‐Yaksi, Dagmar Wachten, Jay Gopalakrishnan   +2 more
openalex   +1 more source

Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy

Advanced Science, EarlyView.
A multifunctional nano immunostimulant is first proposed for efficient tumor immunotherapy. The ER targeted ability, superior ROS production, efficient GSH consumption, coupled with the HIF suppression, jointly arouses ICD/ferroptosis pathways to realize efficient tumor immunotherapy.
Guanhong Guo, Wenda Zhong, Huishuang Zhao, Yueying An, Xinyu Dong, Zhengbo Li, Shuangfeng Qin, Guangzhao Xu, Xiangguo Yue, Xudong Wang, Wen Sun, Zhe‐Sheng Chen, Weiguo Song, Liuya Wei, Fahui Li   +14 more
wiley   +1 more source

Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments. [PDF]

J Cell Biol
Medina M, Chang YT, Rahmani H, Frank M, Khan Z, Fuentes D, Heberle FA, Waxham MN, Barad BA, Grotjahn DA.   +9 more
europepmc   +1 more source

Photothermal–Immunomodulatory Hydrogel Reinforced by Ti3C2/ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

Advanced Science, EarlyView.
A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi, Renliang Zhao, Jia Wang, Zhenchen Xiong, Xiangtian Deng, Cheng Zheng, Wenzhi Zhang   +6 more
wiley   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Prodan-based solvatochromic probes for polarity imaging of organelles

Aknine N, Holban P, Ragaller F, Carravilla P, Gurdap CO, Cetinkaya A, Sezgin E, Klymchenko AS.   +7 more
europepmc   +1 more source

Mechanism of autophagy initiation by transmembrane selective autophagy receptors. [PDF]

EMBO J
Adriaenssens E, Martens S.
europepmc   +1 more source

RAB5 is a host dependency factor for the generation of SARS-CoV-2 replication organelles

Yuexuan Chen, Susanne Klute, Konstantin M. J. Sparrer, Ruth Serra-Moreno   +3 more
openalex   +1 more source