Results 251 to 260 of about 1,088,075 (297)

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

Advanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring, Brian P. Conlon, Edward A. Miao, Blossom Damania, Anna Mae Diehl, Pengda Liu   +14 more
wiley   +1 more source

Localization of Organelle Proteins Using Data-Independent Acquisition (DIA-LOP). [PDF]

Mol Cell Proteomics
McCaskie K, Hutchings C, Feret R, Kim YI, Breckels L, Deery M, Lilley K.   +6 more
europepmc   +1 more source

Acetylation of the Mitochondrial Chaperone GRP75 Governs ER‐Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance

Advanced Science, EarlyView.
Overnutrition exacerbates insulin resistance (IR) and is linked to excessive mitochondrial protein acetylation. However, it remains unclear whether and how mitochondrial protein acetylation influences IR. GCN5L1‐dependent downregulation of GRP75 acetylation at K567/612 consequently enhances ER‐mitochondrial calcium flux and induces ER stress.
Danni Wang, Jiaqi Zhang, Xinyu Yang, Qiqi Zhang, Xiuya Hu, Xin Lu, Hanni Li, Xue Bai, Kai Zhang, Michael N. Sack, Yongsheng Chang, Yingmei Wang, Lingdi Wang, Lu Zhu   +13 more
wiley   +1 more source

Comparative analysis of the mitogenomes of multiple species of Fagaceae, with special focus on Quercus gilva. [PDF]

BMC Plant Biol
Li Y, Zheng SS, Kozlowski G, Song YG.
europepmc   +1 more source

Single Mitochondrion Morphology‐Function Relationship Analysis Using Fluorescent Probes and Artificial Intelligence

Advanced Science, EarlyView.
An integrated strategy combining a mitochondria‐targeted fluorescent probe set and an AI framework enables simultaneous analysis of mitochondrial morphology and function at the single organelle level. By fusing multi‐parametric features, machine learning classification accurately distinguishes individual mitochondria under hypoxia‐related conditions ...
Yang Ding, Bin Fang, Qingzhe Li, Biying Zhang, Jintao Li, Hua Bai, Nicolas H. Voelcker, Bo Peng, Xuekang Yang, Lin Li   +9 more
wiley   +1 more source

Mitochondria Metabolism Regulates Glucose-Lipid Homeostasis in Neurodegenerative Diseases. [PDF]

Research (Wash D C)
Huang J, Zhang C, Huang C, Deng K, Xiao Y, Gao W, Wu M, Lei M.   +7 more
europepmc   +1 more source

Dynamic Synthesis of Multi‐Modal Representations for CITE‐seq Data Integration and Analysis

Advanced Science, EarlyView.
The accurate integration of CITE‐seq modalities faces challenges due to complex RNA‐protein nonlinear interactions and computational inefficiencies. A lightweight framework that adaptively fuses RNA and ADT modalities, and refines them through fine‐grained learning is developed to address this issue.
Yinan Shi, Yanchi Su, Yue Cheng, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +5 more
wiley   +1 more source

Proteomic Analysis of Low-Temperature Stress Response in Maize (<i>Zea mays</i> L.) at the Seedling Stage. [PDF]

Curr Issues Mol Biol
Yu T, Zhang J, Ma X, Cao S, Li W, Yang G.   +5 more
europepmc   +1 more source

Polarization‐Sensitive Holotomography for Multidimensional Label‐Free Imaging and Characterization of Lipid Droplets in Cancer Cells

Advanced Science, EarlyView.
Polarization‐sensitive holotomography (PS‐HT) enables label‐free 3D imaging and quantitative analysis of lipid droplets by exploiting their intrinsic birefringence. Applied to prostate cell models, PS‐HT reveals glucose‐induced lipid accumulation in cancer cells and achieves near‐perfect classification of healthy and cancerous states.
Hossein Khadem, Maria Mangini, Maria Antonietta Ferrara, Anna Chiara De Luca, Giuseppe Coppola   +4 more
wiley   +1 more source

The primary cilium as a multifunctional organelle: emerging roles and unanswered questions. [PDF]

Cell Commun Signal
Corbeil D, Thamm K, Karbanová J, Fargeas CA, Jászai J.   +4 more
europepmc   +1 more source