Results 21 to 30 of about 1,118,522 (291)

Mechanisms of Non-Vesicular Exchange of Lipids at Membrane Contact Sites: Of Shuttles, Tunnels and, Funnels

Frontiers in Cell and Developmental Biology, 2021
Eukaryotic cells are characterized by their exquisite compartmentalization resulting from a cornucopia of membrane-bound organelles. Each of these compartments hosts a flurry of biochemical reactions and supports biological functions such as genome ...
Pascal F. Egea
doaj   +1 more source

The Railmap of Type I Interferon Induction: Subcellular Network Plan and How Viruses Can Change Tracks

Cells, 2022
The innate immune response constitutes the cell’s first line of defense against viruses and culminates in the expression of type I interferon (IFN) and IFN-stimulated genes, inducing an antiviral state in infected and neighboring cells.
Laura Weber, Gabrielle Vieyres
doaj   +1 more source

Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes

Nature Communications, 2018
Mitochondria and peroxisomes require a dynamin-like GTPase to remodel membranes during division. Here the authors identify DYNAMO1, a nucleoside diphosphate kinase-like protein that generates a local source of GTP to promote constriction of the division ...
Yuuta Imoto, Yuichi Abe, Masanori Honsho, Kanji Okumoto, Mio Ohnuma, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, Yukio Fujiki   +7 more
doaj   +1 more source

STING1 in Different Organelles: Location Dictates Function

Frontiers in Immunology, 2022
Stimulator of interferon response cGAMP interactor 1 (STING1), also known as TMEM173, is an immune adaptor protein that governs signal crosstalk that is implicated in many physiological and pathological processes.
Ruoxi Zhang, Rui Kang, Daolin Tang
doaj   +1 more source

Modulation of Ion Transport Across Plant Membranes by Polyamines: Understanding Specific Modes of Action Under Stress

Frontiers in Plant Science, 2021
This work critically discusses the direct and indirect effects of natural polyamines and their catabolites such as reactive oxygen species and γ-aminobutyric acid on the activity of key plant ion-transporting proteins such as plasma membrane H+ and Ca2 ...
Igor Pottosin, Igor Pottosin, Miguel Olivas-Aguirre, Oxana Dobrovinskaya, Isaac Zepeda-Jazo, Sergey Shabala, Sergey Shabala   +6 more
doaj   +1 more source

Plastid origin: who, when and why?

Acta Societatis Botanicorum Poloniae, 2014
The origin of plastids is best explained by endosymbiotic theory, which dates back to the early 1900s. Three lines of evidence based on protein import machineries and molecular phylogenies of eukaryote (host) and cyanobacterial (endosymbiont) genes point
Chuan Ku, Mayo Roettger, Verena Zimorski, Shijulal Nelson-Sathi, Filipa L. Sousa, William F. Martin   +5 more
doaj   +1 more source

A quantitative method to monitor STING degradation with dual-luciferase reporters

Cell Structure and Function
Stimulator of interferon genes (STING) triggers the type I interferon and inflammatory responses against a variety of DNA pathogens, which is essential to limiting viral infection and replication.
Tsumugi Shoji, Kanako Sato, Ayumi Shinojima, Shogo Koide, Ruri Shindo, Kazune Hongo, Kojiro Mukai, Yoshihiko Kuchitsu, Tomohiko Taguchi   +8 more
doaj   +1 more source

Crucial Players for Inter-Organelle Communication: PI5P4Ks and Their Lipid Product PI-4,5-P2 Come to the Surface

Frontiers in Cell and Developmental Biology, 2022
While organelles are individual compartments with specialized functions, it is becoming clear that organellar communication is essential for maintaining cellular homeostasis.
Archna Ravi, Lavinia Palamiuc, Brooke M. Emerling   +2 more
doaj   +1 more source

Live-cell Microscopy and Fluorescence-based Measurement of Luminal pH in Intracellular Organelles

Frontiers in Cell and Developmental Biology, 2017
Luminal pH is an important functional feature of intracellular organelles. Acidification of the lumen of organelles such as endosomes, lysosomes, and the Golgi apparatus plays a critical role in fundamental cellular processes. As such, measurement of the
Li Ma, Li Ma, Qing Ouyang, Qing Ouyang, Gordon C. Werthmann, Heather M. Thompson, Heather M. Thompson, Heather M. Thompson, Eric M. Morrow, Eric M. Morrow, Eric M. Morrow   +10 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source