Results 51 to 60 of about 1,088,075 (297)
Cilia - the prodigal organelle [PDF]
Cilia, 2012 Cilia are the oldest known cellular organelle, first described in 1675 by Anthony van Leeuwenhoek in protozoa [1]. He described them as 'incredibly thin feet, or little legs, which were moved very nimbly'. The term 'cilium' (Latin for eyelash) was probably first coined by Otto Muller in 1786 [2].
Peter K. Jackson, PL Beales
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FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
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Membrane Heterogeneity Beyond the Plasma Membrane
Frontiers in Cell and Developmental Biology, 2020 The structure and organization of cellular membranes have received intense interest, particularly in investigations of the raft hypothesis. The vast majority of these investigations have focused on the plasma membrane of mammalian cells, yielding ...
Hong-Yin Wang +3 more
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STING1 in Different Organelles: Location Dictates Function
Frontiers in Immunology, 2022 Stimulator of interferon response cGAMP interactor 1 (STING1), also known as TMEM173, is an immune adaptor protein that governs signal crosstalk that is implicated in many physiological and pathological processes.
Ruoxi Zhang, Rui Kang, Daolin Tang
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The different facets of organelle interplay—an overview of organelle interactions [PDF]
Frontiers in Cell and Developmental Biology, 2015 Membrane-bound organelles such as mitochondria, peroxisomes, or the endoplasmic reticulum (ER) create distinct environments to promote specific cellular tasks such as ATP production, lipid breakdown, or protein export. During recent years, it has become evident that organelles are integrated into cellular networks regulating metabolism, intracellular ...
Schrader, M +3 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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Bridging molecular and cellular neuroscience with proximity labeling technologies
Experimental and Molecular MedicineProximity labeling (PL) techniques have advanced neuroscience by revealing the molecular interactions that govern neural circuits. From foundational tools such as BioID and APEX to recent innovations such as TurboID and light-activated systems, PL ...
Jun-Gyu Lee +2 more
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Cell biological insights into human STING variants
Cell Structure and FunctionStimulator of interferon genes (STING) is an endoplasmic reticulum (ER)-localized transmembrane protein. STING induces type I interferon and inflammatory responses against a variety of double-stranded DNA (dsDNA) viruses, which is critical for limiting ...
Shogo Koide +5 more
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The Journal of Cell Biology, 2005 In the early 1980s, cell biologists kept slamming into the same obstacle when they tried deploying antibodies to elucidate the working of the Golgi complex. True, use of antibodies to identify proteins (Bader et al., 1982; de Camilli et al., 1983a,b; Huttner et al., 1983; Weiss et al., 1984; Woodcock-Mitchell et al., 1982; Yen and Fields, 1981 ...
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CCT4 promotes tunneling nanotube formation
FEBS Letters, EarlyView.Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto +3 more
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