Results 61 to 70 of about 463,135 (398)

A Validated Set of Fluorescent-Protein-Based Markers for Major Organelles in Yeast (Saccharomyces cerevisiae)

mBio, 2019
Eukaryotic cells share a basic scheme of internal organization featuring membrane-based organelles. The use of fluorescent proteins (FPs) greatly facilitated live-cell imaging of organelle dynamics and protein trafficking.
Jing Zhu, Zheng-Tan Zhang, Shi-Wei Tang, Bo-Song Zhao, Hui Li, Jing-Zhen Song, Dan Li, Zhiping Xie   +7 more
doaj   +1 more source

Coming together to define membrane contact sites. [PDF]

, 2019
Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell ...
De Matteis, Maria Antonietta, Emr, Scott, Giordano, Francesca, Hajnóczky, György, Kornmann, Benoît, Lackner, Laura L., Levine, Tim P., Pellegrini, Luca, Reinisch, Karin, Rizzuto, Rosario, Schuldiner, Maya, Scorrano, Luca, Simmen, Thomas, Stenmark, Harald, Ungermann, Christian   +14 more
core   +6 more sources

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources

The NLRP3–inflammasome as a sensor of organelle dysfunction

Journal of Cell Biology, 2020
Seoane et al. discuss how inflammation driven by the multimolecular NLRP3–inflammasome complex is dependent on organelle dysfunction.
Paula I. Seoane, Bali Lee, Christopher Hoyle, Shi Yu, G. López-Castejón, M. Lowe, D. Brough   +6 more
semanticscholar   +1 more source

Thylakoid redox signals are integrated into organellar-gene-expression-dependent retrograde signalling in the prors1-1 mutant

Frontiers in Plant Science, 2012
Perturbations in organellar gene expression (OGE) and the thylakoid redox state (TRS) activate retrograde signalling pathways that adaptively modify nuclear gene expression (NGE), according to developmental and metabolic needs.
Luca eTadini, Isidora eRomani, Mathias ePribil, Peter eJahns, Dario eLeister, Paolo ePesaresi   +5 more
doaj   +1 more source

Mechanisms of Non-Vesicular Exchange of Lipids at Membrane Contact Sites: Of Shuttles, Tunnels and, Funnels

Frontiers in Cell and Developmental Biology, 2021
Eukaryotic cells are characterized by their exquisite compartmentalization resulting from a cornucopia of membrane-bound organelles. Each of these compartments hosts a flurry of biochemical reactions and supports biological functions such as genome ...
Pascal F. Egea
doaj   +1 more source

BUSCA: An integrative web server to predict subcellular localization of proteins [PDF]

, 2018
Here, we present BUSCA (http://busca.biocomp.unibo.it), a novel web server that integrates different computational tools for predicting protein subcellular localization.
Casadio, Rita, Fariselli, Piero, Martelli, Pier Luigi, Profiti, Giuseppe, Savojardo, Castrense   +4 more
core   +3 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Analysis of sex-differential gene expression on the target of approved drug

Scientific Reports
Sex is a key piece of patient information but is often not actively considered in drug use. This is partly due to the lack of molecular evidence at the gene expression level beyond sex chromosomes and sex hormones.
Yunha Suh, Jun-Gyu Lee, Kwang-eun Kim
doaj   +1 more source

Host upregulation of lipid droplets drives antiviral responses

Cell Stress, 2021
When a host cell is infected by a virus, it activates the innate immune response, setting off a cascade of signalling events leading to the production of an antiviral response.
Ebony A. Monson, Karla J. Helbig
doaj   +1 more source