Results 91 to 100 of about 436,875 (327)
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance
eLife, 2014 Fluctuations in organelle abundance can profoundly limit the precision of cell biological processes from secretion to metabolism. We modeled the dynamics of organelle biogenesis and predicted that organelle abundance fluctuations depend strongly on the ...
Shankar Mukherji, Erin K O'Shea
doaj +1 more source
Biomimetic Iridescent Skin: Robust Prototissues Spontaneously Assembled from Photonic Protocells
Advanced Functional Materials, EarlyView.Uniform nanoparticles are induced to form arrays (photonic crystals) in the cores of biopolymer capsules, endowing these ‘protocells’ with structural color. These protocells are then assembled into large self‐standing objects, i.e., prototissues, with robust mechanical properties as well as iridescent optical properties.
Medha Rath +6 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu +8 more
wiley +1 more source
Endoplasmic Reticulum Dysfunction: An Emerging Mechanism of Vitiligo Pathogenesis
Clinical, Cosmetic and Investigational DermatologyYongyi Xie,1,* Nanhui Wu,1,* Suwei Tang,1,* Zhiyu Zhou,1 Jiashe Chen,1 Jie Li,1 Fei Wu,1 Mingyuan Xu,1 Xiaoxiang Xu,1 Yeqiang Liu,1 Xin Ma1,2 1Shanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University ...
Xie Y +10 more
doaj
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum
Frontiers in Cellular Neuroscience, 2019 The target for the “rapid” (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants.
Kallol Bera +19 more
doaj +1 more source
Charge‐Induced Morphing Gels for Bioinspired Actuation
Advanced Functional Materials, EarlyView.This study introduces a novel electroactive actuation mechanism that enables the gel material to generate substantial and reversible shape‐changing while preserving topological and isochoric (volumetric) equivalence. The resultant morphing behaviors can mimic the movements of muscle‐driven organelles in nature, including cilia‐like beating and ...
Ciqun Xu +4 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo +7 more
wiley +1 more source
Correlation of organelle interactions in the development of non-alcoholic fatty liver disease
Frontiers in ImmunologyOrganelles, despite having distinct functions, interact with each other. Interactions between organelles typically occur at membrane contact sites (MCSs) to maintain cellular homeostasis, allowing the exchange of metabolites and other pieces of ...
Jiabao Liao +9 more
doaj +1 more source