Results 251 to 260 of about 436,875 (327)

Editorial: Targeted Subcellular Delivery of Anti-cancer Agents

Frontiers in Pharmacology, 2019
David A. Jans, Alexander S. Sobolev, Alexander S. Sobolev   +2 more
doaj   +1 more source

Potential Role of Membrane Contact Sites in the Dysregulation of the Crosstalk Between Mitochondria and Lysosomes in Alzheimer's Disease. [PDF]

Int J Mol Sci
Girolimetti G, Calcagnile M, Bucci C.
europepmc   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Landscape expansion microscopy reveals interactions between membrane and phase-separated organelles. [PDF]

J Cell Biol
Zhuang Y, Zhang Z, Dai Z, Shi X.
europepmc   +1 more source

An interphase actin wave promotes mitochondrial content mixing and organelle homeostasis [PDF]

Stephen Coscia, Andrew S. Moore, Cameron P. Thompson, Christian F. Tirrito, E. Michael Ostap, Erika L.F. Holzbaur   +5 more
openalex   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Impact of Drp1 Loss on Organelle Interaction, Metabolism, and Inflammation in Mouse Liver [PDF]

Lixiang Wang, Seiji Nomura, Nao Hasuzawa, Sadaki Yokota, Ayako Nagayama, Kenji Ashida, Junjiro Rikitake, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +9 more
openalex   +1 more source

Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy

Advanced Science, EarlyView.
A multifunctional nano immunostimulant is first proposed for efficient tumor immunotherapy. The ER targeted ability, superior ROS production, efficient GSH consumption, coupled with the HIF suppression, jointly arouses ICD/ferroptosis pathways to realize efficient tumor immunotherapy.
Guanhong Guo, Wenda Zhong, Huishuang Zhao, Yueying An, Xinyu Dong, Zhengbo Li, Shuangfeng Qin, Guangzhao Xu, Xiangguo Yue, Xudong Wang, Wen Sun, Zhe‐Sheng Chen, Weiguo Song, Liuya Wei, Fahui Li   +14 more
wiley   +1 more source

pH variations enable guanine crystal formation within iridosomes. [PDF]

Nat Chem Biol
Eyal Z, Deis R, Gorelick-Ashkenazi A, Barzilay Y, Broder Y, Kellum AP, Varsano N, Hartstein M, Sorrentino A, Rotkopf R, Kaplan-Ashiri I, Rechav K, Metzler R, Houben L, Kronik L, Rez P, Gur D.   +16 more
europepmc   +1 more source

Ultrastructural cellular signatures: does cellular form follow function? [PDF]

, 2019
Auer, Manfred
core   +1 more source