Results 61 to 70 of about 340,460 (357)
Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles
Significance Protein phase separation is a progressive process of high-ordered assembly in vitro, which can experience dynamic liquid–liquid phase separation (LLPS) followed by maturation into pathological solid fibrils.
Jinge Gu+11 more
semanticscholar +1 more source
Peroxisomes: Organelles at the crossroads [PDF]
Recent years have seen remarkable progress in our understanding of the function of peroxisomes in higher and lower eukaryotes. Combined genetic and biochemical approaches have led to the identification of many genes required for the biogenesis of this organelle.
Erdmann, R+3 more
openaire +5 more sources
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit+19 more
wiley +1 more source
We investigated whether the elimination of two major enzymes responsible for triacylglycerol synthesis altered the structure and physical state of organelle membranes under mild heat shock conditions in the fission yeast, Schizosaccharomyces pombe.
Péter Gudmann+6 more
doaj +1 more source
Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions
Melatonin, along with its metabolites, have long been known to significantly reduce the oxidative stress burden of aging cells or cells exposed to toxins. Oxidative damage is a result of free radicals produced in cells, especially in mitochondria.
R. Reiter+5 more
semanticscholar +1 more source
Fluorescent Carbon Dots for Selective Labeling of Subcellular Organelles
With the recent advancement in understanding and control of the structure and optical properties of fluorescent carbon dots (CDs), they have been shown to be valuable in biolabeling of bacteria, tumor cells, tissues, and organelles. Their extremely small
Binesh Unnikrishnan+4 more
semanticscholar +1 more source
In the early 1980s, cell biologists kept slamming into the same obstacle when they tried deploying antibodies to elucidate the working of the Golgi complex. True, use of antibodies to identify proteins (Bader et al., 1982; de Camilli et al., 1983a,b; Huttner et al., 1983; Weiss et al., 1984; Woodcock-Mitchell et al., 1982; Yen and Fields, 1981 ...
openaire +2 more sources
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain+3 more
wiley +1 more source
The Organelle-Specific Regulations and Epigenetic Regulators in Ferroptosis
Ferroptosis is fairly different from other types of cell-death in biochemical processes, morphological changes and genetics as a special programmed cell-death.
Yixuan Zhang+7 more
doaj +1 more source
Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific, membrane‐bound subcellular organelles that derive at least in part from the endolysosomal system but that have unique contents, morphologies and functions to support ...
Shanna L. Bowman+3 more
semanticscholar +1 more source