Results 91 to 100 of about 508,153 (303)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Sorption of ionisable organic compounds by field soils. Part I: acids
, 1991 Sorption of different classes of weak organic acids was measured using soils with a range of pH values, taken from long-term field experiments that had received different amounts of lime. Non-ionisable compounds were used to demonstrate that the soils of
Evans, A. A., Nicholls, P. H.
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Secretion of Organic Acids by Phosphate Solubilizing Bacteria Isolated from Oxisols
Journal of Tropical Soils, 2009 Phosphorus availability is a major limiting for crop production. Bacterial solubilization of insoluble inorganic phosphate has been studied as a means of providing available phosphorus for crop production.
Irfan Dwidya Prijambada +3 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Immobilization and mineralization of nitrogen in pasture soil
, 1972 The results obtained from turf samples indicate that growing plants are mainly responsible for the accumulation of soil organic nitrogenous compounds.
Huntjens, J.L.M.
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Microbiology Indonesia, 2014 Some organic acids derived from lignin degradation in peat soil have significant role in lowering pH of peat soil and have phytotoxic effect for plant.
DIANA NURANI, KOESNANDAR KOESNANDAR
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2013 The objective of this report is to present information on research needs to support improvement of sustainability of organic and low input dairy farms in the EU which could be addressed with on-farm projects.
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Early diagenesis of amino acids in NE Atlantic continental margin sediments
, 2002 This thesis concentrates on early diagenesis of amino acids in sediments across the NE Atlantic continental slope. Early diagenesis comprises the degradation and transformation processes that take place during transport of amino acids through the water
Organic geochemistry & molecular biogeology +5 more
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