Results 101 to 110 of about 3,069,909 (288)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The role of root-released organic acids and anions in phosphorus transformations in a sandy loam soil from Yantai, China

, 2012
One mechanism by which plants can mobilize organic and inorganic forms of phosphorus (P) in soils is by exudation of low-molecular-weight organic acids and anions. However, little is known about their effects on the transformation of P fractions in soils.
Nie, Y. Y., Pei, Y., Xu, G., Blackwell, M. S. A., Shao, H. B., Xu, R. F., Sun, Z. J.   +6 more
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A COMPARISON OF SELECTED MILK INDICATORS IN ORGANIC HERDS WITH CONVENTIONAL HERD AS REFERENCE [PDF]

, 2008
In a historical sense, current organic farming is an old-new alternative under changed world conditions. Organic dairying (O) is an alternative of friendly use of the environment in time of presupposed global climate changes.
Pozdíšek, J., Landová, H., Vyletělová, Marie, Vorlíček, Zdeněk, Hanuš, O., Sojková, K., Roubal, P., Rozsypal, Roman, Genčurová, V.   +8 more
core   +1 more source

Beneficial effects of dietary organic acids on growth and health of juvenile Chinese mitten crab (Eriocheir sinensis)

Aquaculture Reports
The present study determined the effects of five dietary organic acids on the growth and health status of juvenile Eriocheir sinensis. A control diet was without organic acids, and five experimental diets were supplemented with 0.2 % citric acid (CA ...
Zhideng Lin, Yong Lei, Xiaodan Wang, Erchao Li, Chuanjie Qin, Jianguang Qin, Liqiao Chen   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Catalytic hydrogenation of unsaturated organic acids and their sodium salts

, 1986
Catalytic hydrogenation of unsaturated organic acids in methanol and their sodium salts in water was studied at 20 °C and atmospheric pressure of hydrogen using a catalyst of 3% Pd on activated carbon.
Eva Fialová, Vlastimil Růžička, Libor Červený   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source