Results 91 to 100 of about 108,823 (192)

Effects of naringenin on renal expression of organic cation transporter 1 and 2 proteins and metformin disposition in diabetic rats

Journal of Functional Foods, 2019
Modulation of metformin transporters could affect its pharmacokinetics/pharmacodynamics. The effects of naringenin on the renal tubular Organic Cation Transporter 1 (OCT1) and 2 (OCT2) protein expressions and subsequently the metformin clearance in diabetic rats are hereby investigated. Male Sprague Dawley rats were divided into 7 groups.
Edith Pascale Mofo Mato, M. Faadiel Essop, Peter Mark Oroma Owira   +2 more
openaire   +2 more sources

Magnetic fields facilitate DNA-mediated charge transport

, 2015
Exaggerate radical-induced DNA damage under magnetic fields is of great concerns to medical biosafety and to bio-molecular device based upon DNA electronic conductivity.
Lee, Kee Jin, Shao, Fangwei, Shu, Jian-Jun, Wong, Jiun Ru   +3 more
core   +2 more sources

OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Scientific Reports
3D spheroids of primary human hepatocytes (3D PHH) retain a differentiated phenotype with largely conserved metabolic function and proteomic fingerprint over weeks in culture.
Evgeniya Mickols, Alina Meyer, Niklas Handin, Malin Stüwe, Jens Eriksson, Jakob Rudfeldt, Kristin Blom, Mårten Fryknäs, Mikael E. Sellin, Volker M. Lauschke, Maria Karlgren, Per Artursson   +11 more
doaj   +1 more source

Poration by alpha-toxin and streptolysin O [PDF]

, 1989
Ahnert-Hilger, Gudrun, Föhr, Karl Josef, Gratzl, Manfred, Mach, Wolfgang   +3 more
core   +1 more source

Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2.

Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2.
Genetic polymorphisms in xenobiotic transporters have recently been clarified to be associated with change in drug distribution and disposition. To expand on recent identification of direct interaction and functional regulation of several transporters by a PDZ (PSD95, Dlg and ZO1) domain containing protein PDZK1, the effect of mutation in PDZK1 on ...
openaire  

Probing the Molecular Basis of Protein Function through Chemistry [PDF]

, 2006
Adams, Aharoni, Bang, Behrendt, Bieri, Bordignon, Brune, Cashin, Chen, Dawson, Deechongkit, Dong, El-Andaloussi, Fan, Fernandez-Carneado, Fu, Gammeren, Hodges, Holmgren, Holmgren, Jessani, Keppler, Lummis, Mayville, Muir, Orner, Piatesi, Pick, Plante, Rak, Salvatella, Schiene-Fischer, Schofield, Shin, Speers, Vivero-Pol, Werz, Winssinger, Wright   +38 more
core   +3 more sources

The structure of the skeletal muscle calcium channel [PDF]

, 1989
Berwe, Campbell, Chou, Curtis, Ellis, Flockerzi, Flockerzi, Galizzi, Garnier, Hofmann, Hymel, Ildefonse, Jahn, Kaczmarek, Lamb, Leung, Ma, Morton, Nastainczyk, Nowycky, O'Callahan, Pelzer, Rios, Röhrkasten, Schneider, Sieber, Striessnig, Striessnig, Striessnig, Takahashi, Talvenheimo, Tanabe, Tanabe, Trautwein, Vilven, Yatani, Yatani   +36 more
core   +1 more source

Magnesium-mediated stress adaptation in plants: from physio-biochemical insights to climate-resilient agriculture. [PDF]

Front Plant Sci
Sarraf M, Bansal R, Shackira AM, Yadav V, Zarbakhsh S, Roychowdhury R, Chauhan DK, Mousavi H, Hasanuzzaman M.   +8 more
europepmc   +1 more source

A human transporter protein that mediates the final excretion step for toxic organic cations

A human transporter protein that mediates the final excretion step for toxic organic cations
In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous cellular membranes in a transporter-mediated manner. However, the protein transporters involved in the final excretion step are poorly understood.
openaire  

Across species: A comparative perspective on red cell homeostasis and its influence on our understanding of human physiology and disease. [PDF]

Br J Haematol
Connolly KM, Ding P, Wadud R, Rees DC, Brewin JN, Gibson JS.   +5 more
europepmc   +1 more source