Results 251 to 260 of about 36,235 (291)

Gut plasma membrane proteomes reflect the distinct feeding strategies of Nezara viridula and Diaphorina citri. [PDF]

Sci Rep
Mishra R, Arora AK, Jiménez J, Tavares CS, Bonning BC.   +4 more
europepmc   +1 more source

Putative new biomarkers for renal transporter-mediated drug-drug interactions: Characterization as substrates of organic cation transporter 2, multidrug and toxin extrusion protein 1, and other important drug transporters. [PDF]

Drug Metab Dispos
Gessner A, Picurová J, Englhard L, Müller F, Fromm MF, König J.   +5 more
europepmc   +1 more source

Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3 [PDF]

Biomolecules, 2022
Stereoselectivity is well known and very pronounced in drug metabolism and receptor binding. However, much less is known about stereoselectivity in drug membrane transport. Here, we characterized the stereoselective cell uptake of chiral phenylethylamine
Lukas Gebauer, Muhammad Rafehi, Jürgen Brockmöller   +2 more
exaly   +2 more sources

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The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations

Trends in Pharmacological Sciences, 2006
Multidrug and toxic compound extrusion (MATE) proteins, comprising the most recently designated family of multidrug transporter proteins, are widely distributed in all kingdoms of living organisms, although their function is far from understood. The bacterial MATE-type transporters that have been characterized function as exporters of cationic drugs ...
Hiroshi, Omote, Miki, Hiasa, Takuya, Matsumoto, Masato, Otsuka, Yoshinori, Moriyama   +4 more
openaire   +2 more sources

Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4)

Pharmacogenetics and Genomics, 2007
OCTN1 is a multispecific transporter of organic cations and zwitterions, including several clinically important drugs as well as the antioxidant ergothioneine. OCTN1 is highly expressed in the kidney, where it is thought to aid in active secretion of organic cations, and may facilitate the active reabsorption of ergothioneine.
Thomas J, Urban, Chen, Yang, Leah L, Lagpacan, Chaline, Brown, Richard A, Castro, Travis R, Taylor, Conrad C, Huang, Douglas, Stryke, Susan J, Johns, Michiko, Kawamoto, Elaine J, Carlson, Thomas E, Ferrin, Esteban G, Burchard, Kathleen M, Giacomini   +13 more
openaire   +2 more sources

Interplay of the Organic Cation Transporters OCT1 and OCT2 with the Apically Localized Export Protein MATE1 for the Polarized Transport of Trospium

Molecular Pharmaceutics, 2019
The anticholinergic drug trospium is secreted into urine and, to a smaller extent, into bile. Chemically, it is an organic cation, and it is a substrate of the uptake transporters OCT1 and OCT2 as well as for the export proteins MATE1 and MATE2-K as determined in uptake studies using HEK293 cells.
Birgit Deutsch, Claudia Neumeister, Ulrich Schwantes, Martin F. Fromm, Jörg König   +4 more
openaire   +2 more sources

Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1)

Amino Acids, 2013
Asymmetric dimethylarginine (ADMA), inhibiting the nitric oxide (NO) synthesis from L-arginine, is a known cardiovascular risk factor. Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the ...
Joachim, Strobel, Fabian, Müller, Oliver, Zolk, Beate, Endreß, Jörg, König, Martin F, Fromm, Renke, Maas   +6 more
openaire   +2 more sources

Structural Requirements for Drug Inhibition of the Liver Specific Human Organic Cation Transport Protein 1

Journal of Medicinal Chemistry, 2008
The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In this study, we explored the chemical space of registered oral drugs with the aim of studying the inhibition pattern of OCT1 and of developing predictive ...
Gustav, Ahlin, Johan, Karlsson, Jenny M, Pedersen, Lena, Gustavsson, Rolf, Larsson, Pär, Matsson, Ulf, Norinder, Christel A S, Bergström, Per, Artursson   +8 more
openaire   +2 more sources