Results 271 to 280 of about 36,235 (291)

Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model

European Journal of Pharmacology, 2010
This study examined whether doxorubicin therapy alters the expression of heart fatty acid binding protein (H-FABP) and organic cation/carnitine transporter (OCTN2) genes in cardiac tissues, and if so, whether these alterations contributes to doxorubicin-induced cardiotoxicity.
Mohamed M, Sayed-Ahmed, Othman A, Al-Shabanah, Mohamed M, Hafez, Abdulaziz M, Aleisa, Salem S, Al-Rejaie   +4 more
openaire   +2 more sources

Human Organic Cation Transporter 1 Protein Levels of Granulocytes Can Optimize Imatinib Therapy in Patients with Chronic Myeloid Leukemia

Acta Haematologica, 2014
The human organic cation transporter 1 (hOCT1) is the major active influx protein responsible for the transport of imatinib mesylate (IM) into cells. Previous studies have used ¹⁴C-labeled IM to demonstrate a link between chronic myeloid leukemia (CML) molecular response and hOCT1 activity.
Chun, Cao, Xianglong, Li, Ting, Liu, Li, Zhang, Kai, Shen, Huangling, Zhu   +5 more
openaire   +2 more sources

Cellular localization and sex-related protein expression of organic cation transporters oct1 and oct2 in mouse kidneys and liver

2014
Organic cation transporters (OCT ; family SLC22) mediate (re)absorption of various endogenous and exogenous organic cations. In rodents, Oct1/Slc22a1 and Oct2/Slc22a2 are expressed in major excretory organs including kidneys and liver. Due to absence of specific antibodies and corresponding knockout (KO) mice, cellular localization of these ...
Vrhovac Madunić, Ivana, Sabolić, Ivan, Breljak, Davorka, Karaica, Dean   +3 more
openaire   +2 more sources

Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2

Biochemical Pharmacology, 2022
Lukas Gebauer, N Arul Murugan, Ole Jensen   +2 more
exaly  

Characterization of MPP+ secretion across human intestinal Caco-2 cell monolayers: role of P-glycoprotein and a novel Na+ -dependent organic cation transport mechanism

British Journal of Pharmacology, 2000
Kelly Bleasby, Colin D A Brown
exaly  

The inhibitory effects of five alkaloids on the substrate transport mediated through human organic anion and cation transporters

Xenobiotica, 2018
Ling Zhu, Fanfan Zhou
exaly  

Disposition of metformin: Variability due to polymorphisms of organic cation transporters

Annals of Medicine, 2012
Oliver Zolk
exaly  

Ionic transport phenomenon across sol–gel derived organic–inorganic composite mono-valent cation selective membranes

Journal of Membrane Science, 2009
Mahendra Kumar, Bijay P Tripathi
exaly  

Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs

European Journal of Pharmacology, 2004
Michio Takeda, Shinichi Narikawa, Atsushi Enomoto   +2 more
exaly  

Carnitine Transport by Organic Cation Transporters and Systemic Carnitine Deficiency

Molecular Genetics and Metabolism, 2001
Grant A Mitchell, I A Qureshi
exaly