Results 41 to 50 of about 108,823 (192)

Impairment of exocytotic transmitter release by decynium-22 through an inhibition of ion channels

Frontiers in Pharmacology, 2023
Introduction: In addition to members of the family of Na+/Cl− dependent monoamine transporters, organic cation transporters (OCTs), in particular OCT3, as well as the plasma membrane monoamine transporter (PMAT) may contribute to neuronal reuptake of ...
Gabriele Haar, Katsiaryna Hrachova, Tanja Wagner, Stefan Boehm, Klaus Schicker   +4 more
doaj   +1 more source

Carrier-Mediated and Energy-Dependent Uptake and Efflux of Deoxynivalenol in Mammalian Cells

Scientific Reports, 2017
Deoxynivalenol (DON) is one of the most abundant mycotoxins and exerts many adverse effects on humans and animals. To date, the transporting mechanism of DON in mammalian cells remains unclear. In this study, the parallel artificial membrane permeability
Xiaoming Li, Peiqiang Mu, Jikai Wen, Yiqun Deng   +3 more
doaj   +1 more source

Warm seawater temperature promotes substrate colonization by the blue coral, Heliopora coerulea [PDF]

PeerJ, 2019
Background Heliopora coerulea, the blue coral, is a reef building octocoral that is reported to have a higher optimum temperature for growth compared to most scleractinian corals.
Christine Guzman, Michael Atrigenio, Chuya Shinzato, Porfirio Aliño, Cecilia Conaco   +4 more
doaj   +2 more sources

Ischemia/Reperfusion-Inducible Protein Modulates the Function of Organic Cation Transporter 1 and Multidrug and Toxin Extrusion 1 [PDF]

Molecular Pharmaceutics, 2013
The recently identified ischemia/reperfusion-inducible protein (IRIP) has been reported to negatively modulate the activities of several transporters in cell culture systems. The goal of this study is to determine whether IRIP regulates the activities of OCT1 and MATE1, and hence the disposition in vivo of their substrate metformin, a therapeutic drug ...
Qing, Li, Hyekyung, Yang, Xiujuan, Peng, Dong, Guo, Zhongqi, Dong, James E, Polli, Yan, Shu   +6 more
openaire   +2 more sources

How Water's Properties Are Encoded in Its Molecular Structure and Energies. [PDF]

, 2017
How are water's material properties encoded within the structure of the water molecule? This is pertinent to understanding Earth's living systems, its materials, its geochemistry and geophysics, and a broad spectrum of its industrial chemistry. Water has
Brini, Emiliano, Dill, Ken A, Fennell, Christopher J, Fernandez-Serra, Marivi, Hribar-Lee, Barbara, Lukšič, Miha   +5 more
core   +1 more source

Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism. [PDF]

, 2014
Acute kidney injury (AKI) is a common complication of critical illness, and evidence is emerging that suggests AKI disrupts the function of other organs.
Abosaif, Andres-Hernando, Andres-Hernando, Barbara Philips, Boucher, Bougle, Brown, Chan, Chawla, Chung, Doi, Dowling, Dreisbach, Dreisbach, English, Fadillioglu, Gardiner, Gertz, Golab, Group, Gurley, Hassoun, Heinemeyer, Heinemeyer, Iain MacPhee, Izuwa, John Dixon, Karim, Katie Lane, Kirwan, Kirwan, Klein, Kramer, Krueger, Kunihara, Kunuzova, Lane, Lash, Leblanc, Lee, Lee, Lohr, Martyn, Mastorakos, Meier-Hellmann, Michaud, Michaud, Miyazawa, Muntane-Relat, Murakami, Naud, Naud, Nicholson, Nolin, Nolin, Okabe, Okabe, Okabe, Owen, O’Shaunessy, Park, Park, Philips, Power, Schneider, Serteser, Shi, Shibata, Smith, Soni, Spapen, Srinivas, Sun, Tanabe, Tian, Venkatesh, Wang, Whelton, Wilkinson, Wilson, Yamaguchi, Yoshitani, Yu   +82 more
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Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo [PDF]

Cancer Prevention Research, 2017
Abstract Several epidemiologic studies have associated metformin treatment with a reduction in breast cancer incidence in prediabetic and type II diabetic populations. Uncertainty exists regarding which patient populations and/or tumor subtypes will benefit from metformin treatment, and most preclinical in vivo studies have given ...
L Allyson, Checkley, Michael C, Rudolph, Elizabeth A, Wellberg, Erin D, Giles, Reema S, Wahdan-Alaswad, Julie A, Houck, Susan M, Edgerton, Ann D, Thor, Pepper, Schedin, Steven M, Anderson, Paul S, MacLean   +10 more
openaire   +2 more sources

Transcriptional cellular responses in midgut tissue of Aedes aegypti larvae following intoxication with Cry11Aa toxin from Bacillus thuringiensis. [PDF]

, 2015
BackgroundAlthough much is known about the mechanism of action of Bacillus thuringiensis Cry toxins, the target tissue cellular responses to toxin activity is less understood.
Bravo, Alejandra, Cancino-Rodezno, Angeles, Canton, Pablo Emiliano, Gill, Sarjeet S, Soberón, Mario   +4 more
core   +1 more source

ZZE-Configuration of chromophore ß-153 in C-phycocyanin from Mastigocladus laminosus [PDF]

, 1987
The photochemistry of C-phycocyanin has been studied after denaturation in the dark. It shows an irreversible reaction which has characteristics of a Ζ,Ζ,Ε- to Z,Z,Z-isomerization of dihydrobilins. Its amplitude depends on the reaction conditions, with
Bode, W., Fischer, R., Huber, R., Rüdiger, W., Scheer, Hugo, Schirmer, T., Schmidt, G., Siebzehnrübl, S.   +7 more
core   +1 more source

Stress regulated members of the plant organic cation transporter family are localized to the vacuolar membrane

BMC Research Notes, 2008
Background In Arabidopsis six genes group into the gene family of the organic cation transporters (OCTs). In animals the members of the OCT-family are mostly characterized as polyspecific transporters involved in the homeostasis of solutes, the transport
Koch Wolfgang, Küfner Isabell
doaj   +1 more source