Results 91 to 100 of about 24,056 (240)

Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.

PLoS ONE, 2019
The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day
Kei Nishizawa, Noriaki Yoda, Fumi Morokado, Hisakazu Komori, Takeo Nakanishi, Ikumi Tamai   +5 more
doaj   +1 more source

Morin Improves Urate Excretion and Kidney Function through Regulation of Renal Organic Ion Transporters in Hyperuricemic Mice

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. Morin (3,5,7,2′,4′-pentahydroxyflavone), a plant-derived flavonoid, has beneficial effects in animals with various diseases including hyperuricemia and renal dysfunction.
Cai-Ping Wang, Xing Wang, Xian Zhang, Yun-Wei Shi, Lei Liu, Ling-Dong Kong   +5 more
doaj   +1 more source

Designed Lewis Acid–Base Passivation for High Performance Perovskite Solar Cells

Advanced Functional Materials, EarlyView.
ABSTRACT Silicon's high cost and long energy payback time remain major barriers to the global expansion of solar power. In contrast, metal–halide perovskites offer abundant, solution‐processable absorbers, and have achieved efficiencies of 25%–30%, positioning them as strong competitors to silicon.
Afna Manaf, Hiba Shahulhameed, Bhabani Sankar Swain, Shengzhong (Frank) Liu, Adel Najar   +4 more
wiley   +1 more source

Functional Expression of Carnitine/Organic Cation Transporter 1 in Murine Choroid Plexus

Biological and Pharmaceutical Bulletin
Membrane transporters expressed in the choroid plexus (CP) are involved in the transport of substances between the blood and cerebrospinal fluid (CSF). Carnitine/organic cation transporter 1 (OCTN1, also known as SLC22A4) is expressed in rodent CP; however, its specific roles in blood-CSF transport remain unclear.
Ishimoto, Takahiro, Nakamichi, Noritaka, Taguchi, Takayuki, Nishiyama, Misa, Kato, Yukio   +4 more
openaire   +2 more sources

Dynamic Interfacial Chemistry of Choline Chloride as Electrolyte Additive for Stable Zn‐Iodine Batteries

Advanced Functional Materials, EarlyView.
Choline chloride (ChCl) additive enables dynamic interface engineering in Zn‐I2 batteries by forming hydrophobic polyiodide complexes and a Zn‐stabilizing Ch+‐rich layer under electric field modulation. This dual‐function strategy suppresses iodine hydrolysis and dendrite formation, while optimizing Zn2+ solvation and transport for high‐efficiency ...
Xiaoyu Bi, Yuchuan Ren, Ao Yu, Linlin Yang, Ren He, Yapeng Cheng, Xingqi Chang, Xuan Lu, Yanting Xie, Qian Xue, Hu Yuan, Canhuang Li, Runzhou Huang, Jordi Jacas Biendicho, Chaoqi Zhang, Jian Shang, Andreu Cabot   +16 more
wiley   +1 more source

OCT1-Mediated Metformin Uptake Regulates Pancreatic Stellate Cell Activity

Cellular Physiology and Biochemistry, 2018
Background/Aims: Metformin treatment is reported to be associated with a lower incidence of and mortality from pancreatic cancer (PC) in type 2 diabetes patients.
Chunhua Wu, Shanhu Qiu, Xiangyun Zhu, Hao Lin, Ling Li   +4 more
doaj   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Solution‐Processed Thin‐Film Transistors With Tunable Temporal Dynamics for Neuromorphic Computing

Advanced Functional Materials, EarlyView.
Solution‐processed CNT and CNT/P3HT ion‐gated transistors exhibit materials‐defined synaptic timescales: fast CNT devices for high‐frequency spiking and slow hybrid devices for temporal integration. Embedding these dynamics into coupled reservoir‐computing and spiking neural network simulations reveals that a Hybrid‐Reservoir / CNT‐SNN architecture ...
Kevin Schnittker, Haoyi Lin, Zahra Bahrami, Strahinja Marinkovic, Sung Hyun Lee, Joseph Andrews   +5 more
wiley   +1 more source

Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells

Pharmaceutics, 2016
Human hepatoma cells may represent a valuable alternative to the use of human hepatocytes for studying hepatic drug transporters, which is now a regulatory issue during drug development. In the present work, we have characterized hepatic drug transporter
Elodie Jouan, Marc Le Vée, Claire Denizot, Yannick Parmentier, Olivier Fardel   +4 more
doaj   +1 more source

Structure and iron-transporting mechanism of brain organic cation transporter 1

Abstract Brain organic cation transporter 1 (BOCT1), also known as the solute carrier family 22 member 17 (SLC22A17) or the receptor for lipocalin-2 (LCN2), plays critical roles in health and disease. Its deficiency in mice results in early postnatal mortality and severe neurogenesis impairments. Despite its importance in physiology and
Jianan Chen, Shuhao Zhang, Wan Wei, Long Teng, Lei Tao, Kaixuan Gao, Bingqin Li, Aled M Edwards, Hao Fan, Xiangyu Liu, Ligong Chen   +10 more
openaire   +1 more source